[1]尹培,霍红旗,柴鹏,等.PET-CT在胸腹膜转移瘤诊断中的临床价值[J].国际放射医学核医学杂志,2012,36(6):329-333.[doi:10.3760/cma.j.issn.1673-4114.2012.06.003]
　YIN Pei,HUO Hong-qi,CHAI Peng,et al.The clinical value of 18F-FDG PET-CT in diagnosis of the pleural or peritoneal carcinomatosis[J].International Journal of Radiation Medicine and Nuclear Medicine,2012,36(6):329-333.[doi:10.3760/cma.j.issn.1673-4114.2012.06.003]
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
36
期数:
2012年第6期
页码:
329-333
栏目:
PET-CT临床应用及新进展(重点专题)
出版日期:
1900-01-01

文章信息/Info

Title:
The clinical value of 18F-FDG PET-CT in diagnosis of the pleural or peritoneal carcinomatosis
作者:
尹培;  霍红旗;  柴鹏;  赵剑平;  冯小伟;  刘春海;  游志鑫
邯郸市中心医院核医学科, 邯郸 056001
Author(s):
YIN Pei;  HUO Hong-qi;  CHAI Peng;  ZHAO Jian-ping;  FENG Xiao-wei;  LIU Chun-hai;  YOU Zhi-xin
Department of Nuclear Medicine, Handan Central Hospital, Handan 056001, China
关键词:
胸膜; 腹膜; 肿瘤转移; 氟脱氧葡萄糖F18; 正电子发射断层显像术; 体层摄影术; X线计算机
Keywords:
Pleura; Peritoneum; Neoplasms metastasis; Fluorodeoxyglucose F18; Positron emission tomography; Tomography;  X-ray computed
DOI:
10.3760/cma.j.issn.1673-4114.2012.06.003
摘要:
目的 评价PET-CT在胸腹膜转移瘤诊断中的临床价值。方法 回顾性分析具有原发恶性肿瘤病史及不明原因胸腹腔积液,临床高度怀疑胸腹膜转移瘤的37例患者资料。全部患者均行18F-FDG PET-CT全身显像,经病历记录分析、肿瘤标志物检测、病理检查或临床随访最终判断是否存在胸腹膜转移瘤,并对已确诊胸腹膜转移瘤的患者记录病灶代谢分布形态及测量最大标准化摄取值(SUVmax)。结果 37例行18F-FDG PET-CT全身显像的患者中,PET-CT诊断阳性的患者共29例,其中,假阳性3例;诊断为阴性的患者共8例,其中,假阴性2例。18F-FDG PET-CT全身显像诊断胸腹膜转移瘤的灵敏度为92.9%、特异度为66.7%、准确率为86.5%、阳性预测值为89.7%、阴性预测值为75%.在已确诊胸腹膜转移瘤的26例患者的全身显像中,病灶摄取形态呈条形或环形分布者11例、呈点灶状分布者15例,两组病灶SUVmax分别为5.97±3.39和2.89±0.92,差异具有统计学意义(t=2.93,P<0.05)。结论 PET-CT全身显像在胸腹膜转移瘤的诊断中具有简单、无创和灵敏度高等优点,是一种理想的判断胸腹膜转移瘤的方法,具有较高的临床应用价值。
Abstract:
Objective To evaluate the clinical value of 18F-FDG PET-CT in diagnosis of the pleural or peritoneal carcinomatosis. Methods A total of 37 patients with pleural effusion or ascites of unknown origin were analyzed retrospectively. All patients underwent whole body 18F-FDG PET-CT. The 18F-FDG distributional pattern and the maximum standardized uptake value(SUVmax) of lesions were analyzed. The final diagnosis of all cases were established based on the results of catamnestic analysis, tumor markers assay, histopathology or clinical follow-up. Results Of all the 37 cases, 29 had positive findings on 18F-FDG PET-CT, of which 26 were pleural or peritoneal carcinomatosis and 3 were pleural or peritoneal tuberculosis; 8patients had negative findings on 18F-FDG PET-CT, of which 6 were pleural or peritoneal benign lesions and 2 were peritoneal carcinomatosis. The sensitivity, specificity, accuracy, positive predictive value, negative predictive value of 18F-FDG PET-CT in diagnosis of peritoneal carcinomatosis were 92.9%, 66.7%, 86.5%, 89.7% and 75.0% respectively. The SUVmax between the ring-form and strip-type lesions were significantly different(5.97±3.39 vs. 2.89±0.92, t=2.93, P<0.05). Conclusions 18F-FDG PET-CT is simple, noninvasive and high sensitive in detecting pleural or peritoneal carcinomatosis, and may be an ideal technique of highly clinical usefulness in the diagnosis of the pleural or peritoneal carcinomatosis.

参考文献/References:

[1] Dromaine C,Leboulleux S,Auperin A,et al.Staging of peritoneal carcinomatasis:enhanced CT vs.PET/CT.Abdom Imaging,2008,33(1):87-93.
[2] 王晓燕,张祥松,陈志丰,等.18F-FDG PET/CT诊断腹膜转移瘤的临床价值.中华核医学杂志,2010,30(2):98-100.
[3] Soussan M,Des Guetz G,Barrau V,et al.Comparison of FDG-PET/CT and MR with diffusion-weighted imaging for assessing peritoneal carcinomatosis from gastrointestinal malignancy.Eur Radiol,2012,22(7):1479-1487.
[4] Kim JH,Song HC,Chong A,et al.Comparison of diagnostic accuracy between F-18FDG PET/CT and conventional enhanced CT in detection of pleural metastasis in patients with non-small cell lung cancer.J Nucl Med,2010,51 Suppl 2:119.
[5] Kang JY,Kim SK,Kim TS.Comparison of FDG PET/CT with contrast-enhanced CT for the detection of peritoneal carcinomatosis in patients with ovarian cancer.J Nucl Med,2009,50 Suppl 2:1705.
[6] 陆国秀,张彩霞,徐薇娜,等.18F-FDG PET/CT对恶性胸膜间皮瘤诊断及预后评估的价值.同位素,2012,25(1):58-63.
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相似文献/References:

[1]陆东燕,侯莎莎,丁恩慈,等.结核性与恶性腹膜弥漫性病变的18F-FDG PET/CT影像特征分析[J].国际放射医学核医学杂志,2014,38(6):398.[doi:10.3760/cma.j.issn.1673-4114.2014.06.012]
　Lu Dong-yan,Hou Sha-sha,Ding En-ci,et al.Analysis of 18F-FDG PET/CT imaging features of tuberculous and cancerous diffuse peritoneal lesions[J].International Journal of Radiation Medicine and Nuclear Medicine,2014,38(6):398.[doi:10.3760/cma.j.issn.1673-4114.2014.06.012]

备注/Memo

备注/Memo:
收稿日期:2012-08-13。
通讯作者:霍红旗(Email:13931018801@163.com)
更新日期/Last Update: 1900-01-01