[1]陈贵兵,黄劲雄,何小江,等.99Tcm-MIBI诊断重度淤胆型婴儿肝炎综合征的价值[J].国际放射医学核医学杂志,2010,34(3):168-170.
 CHEN Gui-bing,HUANG Jin-xiong,HE Xiao-jiang,et al.99Tcm-MIBI hepatobiliary scintigraphy in peadiatric patients with severe cholestatic infant hepatitis syndrome[J].International Journal of Radiation Medicine and Nuclear Medicine,2010,34(3):168-170.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
34
期数:
2010年第3期
页码:
168-170
栏目:
临床核医学
出版日期:
1900-01-01

文章信息/Info

Title:
99Tcm-MIBI hepatobiliary scintigraphy in peadiatric patients with severe cholestatic infant hepatitis syndrome
作者:
陈贵兵1 黄劲雄1 何小江1 罗作明1 卢正远2 吴华1
1. 厦门大学附属第一医院核医学科, 361000;
2. 厦门大学附属第一医院新生儿科, 361000
Author(s):
CHEN Gui-bing1 HUANG Jin-xiong1 HE Xiao-jiang1 LUO Zuo-ming1 LU Zheng-yuan2 WU Hua1
Department of Nuclear Medicine, The First Affiliated Hospital of Xiamen University, Xiamen 361003, China
关键词:
胆汁淤积肝炎婴儿99m锝甲氧基异丁基异腈99m锝二乙基-亚氨基二乙酸
Keywords:
CholestasisHepatitisInfantTechnetium 99Tcm sestamibiTechnetium 99Tcm diethyliminodiacetic acid
分类号:
10.3760/cma.j.issn.1673-4114.2010.03.011
摘要:
目的 鉴于99Tcm-二乙基亚氨基二乙酸(99Tcm-EHIDA)肝胆显像对临床重度淤胆患儿应用的局限性,试用99Tcm-甲氧基异丁基异腈(99Tcm-MIBI)作为新的肝胆显像剂,了解其应用基础及对重度淤胆患儿的初步诊断价值.方法 建立胆总管闭锁动物模型,了解99Tcm-MIBI肝胆显像的应用基础;对重度淤胆并最终临床证实为婴儿肝炎综合征的27例患儿先行常规99Tcm-EHIDA肝胆显像,次日行24 h延迟显像,1 h后再行99Tcm-MIBI肝胆显像.比较两种显像剂对重度淤胆型婴儿肝炎综合征的诊断价值.结果 动物实验证明,99Tcm-MIBI确经肝胆排泄,且无明显肠道自分泌现象,可以用作肝胆显像.初步临床诊断表明,99Tcm-MIBI肝胆显像对重度淤胆型婴儿肝炎综合征的诊断灵敏度达100%,远远高于常规99Tcm-EHIDA肝胆显像(66.67%).结论 对临床高度怀疑的重度淤胆型婴儿肝炎综合征,99Tcm-MIBI肝胆显像的诊断灵敏度明显高于常规99Tcm-EHIDA肝胆显像.
Abstract:
Objective Because of the limited of 99Tcm-diethyl iminodiacetic acid (99Tcm-EHIDA)hepatobiliary scintigraphy in the diagnosis of severe cholestatic infant hepatitis syndrome, trial use 99Tcm-methoxy isobutyl isonitrile (99Tcm-MIBI) as a new hepatobiliary scintigraphy imaging agent to understand its applied basis and primary evaluate value in diagnosis of severe cholestatic infant hepatitis syndrome.Methods Constructed choledochal atresia animal model and investigated the application basis of 99Tcm-MIBI hepatobiliary scintigraphy. Twenty-seven children patients of severe cholestatic who finally confirmed infant hepatitis syndrome were underwent firstly 99Tcm-EHIDA hepatobiliary scintigraphy. After 24 h delay imaging next day, 99Tcm-MIBI hepatobiliary scintigraphy was underwent after 1 h. Two imaging agents of value in the diagnosis of severe cholestatic infant hepatitis syndrome were compared. Results It was proved that 99Tcm-MIBI was surely excreted by hepatobiliary and had no intestinal autocrine phenomenon in animal test. So 99Tcm-MIBI can be used to undergo hepatobiliary scintigraphy. The sensitivity of 99Tcm-MIBI hepatobiliary scintigraphy in the diagnosis of severe cholestatic infant hepatitis syndrome was 100% in our primary clinical study. Its sensitivity was higher than which of 99Tcm-EHIDA hepatobiliary scintigraphy (66.67%) by far.Conclusions With regard to those children patients who suspected highly severe cholestatic infant hepatitis syndrome in clinical, the sensitivity of 99Tcm-MIBI hepatobiliary scintigraphy is obviously superior to conventional 99Tcm-EHIDA hepatobiliary scintigraphy.

参考文献/References:

[1] 旲晶,缪蔚冰,林军,等.放射性核素肝胆显像诊断先天性胆道闭锁的临床价值.实用医技杂志.2006,13(24):4350-4351.
[2] 杨吉刚,李存林.邹兰芳,等.99mTc-EHIDA肝胆显像在先天性胆道闭锁诊断中的价值.实用儿科临床杂志,2005,20(10):1050-1051.
[3] Poddar U,Bhattacharya A,Thapa BR,et al.Ursodeoxy-cholic arid-augmented hepatobiliary scintigraphy in the evaluation of neonatal jaundice. J Nucl Med, 2004,45(9):1488-1492.
[4] Esmaili J, lzadyar S, Karegar I, et al. Biliary atresia in infants with prolonged cholestatic jaundice:diagnostic accuracy of hepatobiliary scintigraphy. Abdom Imaging, 2007, 32(2):243-247.
[5] Stipsanelli K, Koutsikos J, Papantoniou V, et al. Hepatobiliary scintigraphy and gamma-GT levels in the differential diagnosis of extrahepalic biliary atresia. Q J Nucl Med Mol Imaging, 2007, 51(1):74-81.
[6] 陈维安,李春亿.梁宏,等.99Tcm-二乙基乙酰替苯胺亚氨二醋酸显像在婴儿持续性黄疸鉴别诊断中的意义.实用儿科临床杂志, 2007. 22(7):502-503.
[7] 侯先存.程华,李智勇.等.苯巴比妥钠介入99mTc-EHIDA肝明显像诊断先天性胆道闭锁的价值.中国医学影像技术,2008. 24(8):1261-1263.

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备注/Memo

备注/Memo:
收稿日期:2009-11-18。
通讯作者:吴华(E-mail:wuhuaa@hotmail.com)
更新日期/Last Update: 1900-01-01