[1]柴黎明,杨小丰,王爽,等.多巴胺转运体显像剂11C-CFT和18F-CFT及其临床应用进展[J].国际放射医学核医学杂志,2009,33(4):232-234.[doi:10.3760/cma.j.issn.1673-4114.2009.04.012]
　CHAI Li-ming,YANG Xiao-feng,WANG Shuang,et al.Dopamine transporter imaging agent 11C-CFT and 18F-CFT and its clinical application development[J].International Journal of Radiation Medicine and Nuclear Medicine,2009,33(4):232-234.[doi:10.3760/cma.j.issn.1673-4114.2009.04.012]
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
33
期数:
2009年第4期
页码:
232-234
栏目:
临床核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Dopamine transporter imaging agent 11C-CFT and 18F-CFT and its clinical application development
作者:
柴黎明1;  杨小丰1;  王爽2;  吴君2;  赵周社2
1. 新疆维吾尔自治区人民医院核医学科, 乌鲁木齐, 830001;
2. 通用电气(中国)医疗系统集团, 北京, 100176
Author(s):
CHAI Li-ming1;  YANG Xiao-feng1;  WANG Shuang2;  WU Jun2;  ZHAO Zhou-she2
1. Department of Nuclear Medicine, Xinjiang People’s Hospital, Urumchi 830001, China;
2. GE HealthcareChina, Beijing 100176, China
关键词:
多巴胺质膜转运蛋白质类; 托烷类; 正电子发射断层显像术
Keywords:
Dopamine plasma membrane transport proteins; Tropomes; Positron-emission tomography
DOI:
10.3760/cma.j.issn.1673-4114.2009.04.012
摘要:
使用11C和18F标记的托烷类衍生物的正电子显像剂是目前临床常规使用的正电子显像剂,11C标记的显像剂11C-2β-碳甲氧基-3β-(4-氟苯基)托烷(11C-CFT)具有合成方法简单、比活度高、成本低等优点,但是11C半衰期太短而限制了其临床使用;18F-CFT具有半衰期长、临床使用方便而受到重视。11C-CFT和11F-CFT PET均被用于临床早期诊断帕金森病和对药物治疗疗效的监测。
Abstract:
18F and 11C marked tropane derivatives is routing used PET tracer. 11C marked 11C-2β.carbomethoxy-3β-(4-fluorophenyl) tropane (11C-CFT) synthesis method is simple, have high specific activity and low cost, but 11C short half life limited the clinical application of 11C-CFT.18F-CFT was much accounted of due to long half life and easy to access.11C-CFT and 18F-CFT was both used in Paricinson disease early diagnosis and monitoring of pharmaceutical theraoy.

参考文献/References:

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[5] Rinne JO,Ruottinen H,Bergman J,et al.Usefulness of a dopamine transporter PET ligand[(18)F] beta-CFT in assessing disability in Parkinson’s disease.J Neurol Neurosurg Psychiatry,1999,67(6):737-741.
[6] 张锦明,田嘉禾,郭喆,等.在线自动化制备多巴胺转运蛋白显像剂11C-β-CFT,中华核医学杂志,2005,25(3):142-145.
[7] Haaparanta M,Bergman J,Laakso A,et al.[18F] CFT ([l8F] WIN 35,428),a radioligand to study the dopamine transporter with PET;biodistribution in rats.Synapse,1996,23(4):321-327,
[8] Chitneni SK,Garreau L,Cleynhens B,et al.Improved synthesis and metabolic stability analysis of the dopamine transporter ligand[18F] FECT.Nucl Med Biol,2008,35(1); 75-82.
[9] Emond P,Guilloteau D,Chalon S.PE2I:a radiopharmaceutical for in vivo exploration of the dopamine transporter.CNS Neurosci Ther,2008,14(1):47-64.
[10] Ouchi Y,Kanno T,Okada H,et al.Changes in dopamine availability in the nigrostriatal and mesocortical dopaminergic systems by gait in Parkinson’s disease.Brain,2001,124(pt 4):784-792.
[11] Rinne JO,Laine M,Kaasinen V,et al.Striatal dopamine transporter and extrapyramidal symptoms in frontotemporal dementia.Neurology,2002,58(10):1489-1493.
[12] Weng YH,Yen TC,Chen MC,et al.Sensitivity and specificity of 99mTc-TRODAT-l SPECT imaging in differentiating patients with idiopathic Parkinson’s disease from healthy subjects.J Nucl Med,2004,45(3):393-401.
[13] 何婷婷,王瑞民,陈英茂,等.多巴胺转运蛋白PET成像诊断帕金森病.中国医学影像学杂志,2008,16(2):94-97.
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相似文献/References:

[1]于江,段玉清,毕常芬,等.多巴胺转运体PET显像剂11C-Altropane的研究进展[J].国际放射医学核医学杂志,2018,(1):74.[doi:10.3760/cma.j.issn.1673-4114.2018.01.014]
　Yu Jiang,Duan Yuqing,Bi Changfen,et al.Progress of dopamine transporter PET imaging agent 11C-Altropane[J].International Journal of Radiation Medicine and Nuclear Medicine,2018,(4):74.[doi:10.3760/cma.j.issn.1673-4114.2018.01.014]
[2]朱毓华,鲁佳荧,张慧玮,等.FBP和OSEM对正常人脑内多巴胺转运体分布半定量值影响的研究[J].国际放射医学核医学杂志,2018,(5):409.[doi:10.3760/cma.j.issn.1673-4114.2018.05.004]
　Zhu Yuhua,Lu Jiaying,Zhang Huiwei,et al.Effects of the different PET image reconstruction methods on distribution of dopamine transporter in healthy human brain[J].International Journal of Radiation Medicine and Nuclear Medicine,2018,(4):409.[doi:10.3760/cma.j.issn.1673-4114.2018.05.004]

备注/Memo

备注/Memo:
收稿日期:2009-03-19。
通讯作者:柴黎明,E-mail:chailm@126.com
更新日期/Last Update: 1900-01-01