[1]程艳,王斌全,李思进,等.SPECT-CT探测喉癌前哨淋巴结[J].国际放射医学核医学杂志,2008,32(5):268-271.
　CHENG Yan,WANG Bin-quan,LI Si-jin,et al.Sentinel lymph node detection by SPECT-CT in patient with laryngeal carcinoma[J].International Journal of Radiation Medicine and Nuclear Medicine,2008,32(5):268-271.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
32
期数:
2008年第5期
页码:
268-271
栏目:
临床核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Sentinel lymph node detection by SPECT-CT in patient with laryngeal carcinoma
作者:
程艳1;  王斌全2;  李思进1;  皇甫辉2;  刘涛2;  柴向斌2
1. 030001 太原, 山西医科大学第一医院核医学科;
2. 030001 太原, 山西医科大学第一医院耳鼻喉科
Author(s):
CHENG Yan1;  WANG Bin-quan2;  LI Si-jin1;  HUANG Fu-hui2;  LIU TAo2;  CHAI Xiang-bin2
1. Department of Nuclear Medicine, Taiyuan 030001, China;
2. Department of Otorhinolaryngology, the First Hospital of Shanxi Medical University, Taiyuan 030001, China
关键词:
喉肿瘤; 淋巴转移; 体层摄影术; 发射型计算机; 单光子; 体层摄影术; X线计算机; 前哨淋巴结
Keywords:
Laryngeal neoplasms; Lymphatic metastasis; Tomography;  emission-computed;  single-photon; Tomography;  X-ray computed; Sentinel lymph node
摘要:
目的 评价SPECT-CT淋巴显像探测喉癌患者前哨淋巴结(SLN)的价值。方法 30例临床N0期喉癌患者,术前于喉镜引导下注射99Tcm-硫胶体(SC),使用SPECT-CT进行SLN显像;同时,术中用γ探测仪探测放射性"热点"。将手术切除的SLN及颈清扫标本行病理检查。结果 全组30例检出SLN28例,检出率为93.3%。术前平面显像、SPECT-CT分别检出61个和66个SLN。术中用手持式γ探测仪有27例患者探测到SLN,共计70个,检出率为90.0%(27/30)。γ探测仪探测SLN数目与SPECT-CT淋巴显像数目有4例不一致,24例符合,其符合率为85.7%(24/28)。病理结果显示,6例患者有淋巴结转移,占20.0%。SLN检测的灵敏度、特异度、准确率和假阴性率分别为83.3%、95.8%、93.3%和16.7%。结论 术前SPECT-CT淋巴显像能有效探测喉癌患者的SLN,准确预测颈部淋巴结转移情况。
Abstract:
Objective To evaluate the value of SPECT-CT lymphoscintigraphy for sentinel lymph node (SLN) detection in patients with larynx neoplasms.Methods Thirty patients with cN0 laryngeal carcinoma were eligible for the study.Preoperative SPECT-CT lymphoscintigraphy was performed with laryngotracheoscopy guided injection of radioactivity isotope 99Tcm-sulfur colloid (99Tcm-SC) into the laryngeal carcinoma before surgery.The patients underwent intraoperative lymphatic mapping with a handheld gamma-detecting probe.The results of routine pathologic examination of cervical specimen were set a golden standard to assess the efficacy of SLN biopsy in evaluating the cervical lymph node status.Results Sixty-six SLNs were detected in 28 cases out of the total 30 cases (93.3%).Preoperative planar image and SPECT-CT fusion image detected 61 and 66 SLNs, respectively.With the application of intraoperative gamma probe, SLN was detected in 27/30 patients (90.0%), correlate rate was 85.7% (24/28).Six patients (20.0%) had lymph node metastasis.The sensitivity, specificity, accuracy and false negative rate of SLN detection were respectively 83.3%, 95.8%, 93.3% and 16.7%.Conclusion Preoperative SPECT-CT lymphoscintigraphy can not only enables precise localization of SLN but also detect the cervical lymph node metastasis in patients with laryngeal carcinoma.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2008-04-08。
基金项目:国家自然科学基金(30772405);山西省研究生优秀创新重点项目(20081010)
通讯作者:王斌全(E-mail:wxq_xy@yahoo.com.cn)
更新日期/Last Update: 1900-01-01