[1]徐文清,高文远,沈秀,等.银耳多糖注射剂保护辐射损伤小鼠造血功能的研究[J].国际放射医学核医学杂志,2006,30(2):114-116.
　XU Wen-qing,GAO Wen-yuan,SHEN Xiu,et al.Protective effect study of polysaccharides from tremella fuciformis on hematopoietic function in radiation-injured mice[J].International Journal of Radiation Medicine and Nuclear Medicine,2006,30(2):114-116.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
30
期数:
2006年第2期
页码:
114-116
栏目:
放射生物学
出版日期:
1900-01-01

文章信息/Info

Title:
Protective effect study of polysaccharides from tremella fuciformis on hematopoietic function in radiation-injured mice
作者:
徐文清1; 2;  高文远1;  沈秀2;  王月英2;  刘培勋2
1. 300070 天津, 天津大学药学院天然药物学研究室;
2. 300192 天津, 中国医学科学院放射医学研究所药学研究室
Author(s):
XU Wen-qing1; 2;  GAO Wen-yuan1;  SHEN Xiu2;  WANG Yue-ying2;  LIU Pei-xun2
1. Department of Natural Pharmaceutics, The College of Pharmaceuticals and Biotechnology, Tianjin University, Tianjin 300072, China;
2. Department of Pharmaceutics, The Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Tianjin 30019
关键词:
银耳多糖; 辐射损伤; 造血功能
Keywords:
Polysaccharides; tremella; Radiation injuries; Hematopoietic function
分类号:
R818.74
摘要:
目的 研究银耳多糖注射剂对辐射损伤小鼠造血功能的防护作用。方法 用内源性脾结节形成,股骨有核细胞计数及脾脏指数等方法观察银耳多糖在6mg/kg、12mg/kg、24mg/kg三个剂量时对137Csγ射线照射7.5Gy后小鼠造血功能的影响。结果 照射前连续3d给药,照后第9天受照小鼠的股骨有核细胞数、脾结节和脾指数与对照组相比有明显的增高,经统计学处理有显著性差异。结论 银耳多糖对辐射损伤小鼠造血系统具有保护作用。
Abstract:
Objective To study the protective effects of polysaceharides of Tremella fueiformis on hematopoietic function in radiation-injured mice.Methods Colony-forming unit of spleen(CFU-S), number of nucleated cells in bone marrow (BMNC) and spleen index were used to investigated the effect of polysaccharides from tremella fuciformis at 6mg/kg、12mg/kg、24mg/kg on hematopoietic function of mice irradiated with 7.5 Gy 137Csγ-rays.Results On the 9 th day after irradiation compared with the negative control group number of nucleated cells in bone marrow, colony-forming unit of spleen and spleen index of mice have treated with polysaccharides from Tremella fuciformis intraperitoneally for three days prior to irradiation increased markedly.Conclusion Polysaccharides of tremella fuciformis have protective effect on hematopoietic function of radiation-injured mice.

参考文献/References:

1 郑仕中. 银耳的化学成分和药理研究进展. 中国药学杂志, 1993, 28(5):164-267.
2 中华人民共和国卫生部药政局.新药临床前研究指导原则汇编.1993.
3 杨福军, 王汝勤, 赵云庭, 等. E838对造血组织的放射防护作用. 中国肿瘤临床, 1998, 25(11):832-833.
4 黄霞, 刘杰, 刘惠霞, 等. 熟地黄多糖对血虚模型小鼠的影响. 中国中药杂志, 2004, 29(12):1168-1173
5 席亚明, 席亚荣, 孙延庆, 等. 梁金菇多糖对辐射损伤小鼠造血功能的影响. 中华放射医学与防护杂志, 2002, 2(4):291-293
6 周永, 糜漫天, 杨镇洲. 三轻异黄酮对照射小鼠造血系统损伤的防护作用. 中华放射医学与防护杂志, 2002, 25(1):21-24

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备注/Memo

备注/Memo:
收稿日期:2005-12-28。
基金项目:天津市科技发展计划应用基础重点项目(033801711)
通讯作者:徐文清(E-mail:xuwenqing67@yahoo.com.cn)
更新日期/Last Update: 1900-01-01