[1]秦丽莉,张春明.单链抗体研究进展及其在医学中的应用[J].国际放射医学核医学杂志,2005,29(6):255-257.
　QIN Li-li,ZHANG Chun-ming.The research progress and medicine application of the ScFv antibody[J].International Journal of Radiation Medicine and Nuclear Medicine,2005,29(6):255-257.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
29
期数:
2005年第6期
页码:
255-257
栏目:
核医学
出版日期:
1900-01-01

文章信息/Info

Title:
The research progress and medicine application of the ScFv antibody
作者:
秦丽莉;  张春明
300192 天津, 中国医学科学院中国协和医科大学放射医学研究所
Author(s):
QIN Li-li;  ZHANG Chun-ming
Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China
关键词:
单链抗体; 免疫显像诊断; 靶向治疗
Keywords:
single-chain antibody; immunoimage diagnose; targeted therapy
分类号:
Q511
摘要:
自英国和日本学者发现白喉抗毒素以来,人们对于抗体的研究经历了多克隆抗体、单克隆抗体和基因工程抗体3个阶段,其中单链抗体由于具有相对分子质量小、穿透力强、血中半衰期短、抗原结合特异性强、免疫原性弱和可在原核细胞中表达等特点而倍受人们关注。
Abstract:
Since the scholar of England and Japan had found the diphtheria antitoxin, the research of the antibody has experienced three phases:polyclonal antibodies, monoclonal antibodies and genetically engineered antibodies. In recent years, far more attention has been paid to single-chain antibody by researchers owing to it’s small molecular, strong ability of penetration, short half-lives in blood, high specificity to combine with the corresponding antibody, weak immunogenicity and possibility to be expressed in prokaryocyte.

参考文献/References:

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5 Hagemeyer CE, Tomic I, Jaminet P, et al. Fibrin-targeted direct factor Xa inhibition:construction and characterization of a recombinant factor Xa inhibitor composed of an anti-fibrin single-chain antibody and tick anticoagulant peptide[J]. Thromb Haemost.2004, 92(1):47-53.
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8 Yoshida S, Kobayashi T, Matsuoka H, et al. T-cell activation and cytokine production via a bispeciflc single-chain antibody fragment targeted to blood-stage malaria parasites[J]. Blood, 2003, 101(6):2300-2306.
9 Zhong Y, Cheng J, Shi S, et al. Screening and application of humanderived HBsAg bacteriophage single chain antibody in clinical diagnosis[J]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi,2002, 16(3):223-225.
10 Russell JS, Raju U, Gumin GJ, et al. Inhibition of radiation-induced nuclear factor-κB activation by an anti-Ras single-chain antibody fragment[J]. Cancer Res, 2002, 62(8):2318-2326.
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相似文献/References:

[1]洪智慧,周小林,石怡珍,等.131I标记抗胃泌素释放前体单链抗体的制备及其稳定性和免疫活性研究[J].国际放射医学核医学杂志,2010,34(2):107.[doi:10.3760/cma.j.issn.1673-4114.2010.02.013]
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[2]谭文庆.单链抗体的研究进展[J].国际放射医学核医学杂志,2001,25(2):55.
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备注/Memo

备注/Memo:
收稿日期:2005-01-28。
基金项目:天津市科技攻关培育项目资助(043102211)
更新日期/Last Update: 1900-01-01