[1]孙晓蓉,邢力刚.18F-FLT实验研究与临床应用进展[J].国际放射医学核医学杂志,2004,28(2):63-66.
　SUN Xiao-rong,XING Li-gang.The experimental study and clinical application progress of 18F-fluorothymidine[J].International Journal of Radiation Medicine and Nuclear Medicine,2004,28(2):63-66.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
28
期数:
2004年第2期
页码:
63-66
栏目:
核医学
出版日期:
1900-01-01

文章信息/Info

Title:
The experimental study and clinical application progress of 18F-fluorothymidine
作者:
孙晓蓉;  邢力刚
250117 济南, 山东省肿瘤防治研究院PET/CT中心
Author(s):
SUN Xiao-rong;  XING Li-gang
PET/CT Center, Shandong Cancer Hospital and Institute, Shandong Jinan 250117, China
关键词:
氟放射性同位素; 胸苷; 正电子发射体层显像
Keywords:
fluorine-18 nuclide; thymidine; positron emission tomography
分类号:
R817
摘要:
放射性核素标记的胸腺嘧啶类似物能够在一定程度上反映细胞增殖的状况,3’-脱氧-3’-18F-氟代胸苷(3’-deoxy-3’-18F-fluorothymidine,18F-FLT)是此类药物中发展较为完善的一种示踪剂。18F-FLT PET通过反映胸苷激酶-1的活性而间接反映肿瘤细胞的增殖状况,有助于对肿瘤进行良恶性鉴别、疗效评估和预后判断,是一种具有良好应用前景的PET显像剂。
Abstract:
3’-deoxy-3’-18F-fluorothymidine (18F-FLT)is a promising tracer derived from thymidine. Accumulation of 18F-FLT is dependent on cellular thymidine kinase-1 (TK-1)activity. This enzyme is functional only in cells undergoing DNA replication during the S phase of the cell cycle.18F-fluorothymidine PET thus be able to image of cell proliferation in vivo for diagnosis, staging and monitoring of treatment re-sponse. Its advancements in basic and clinical studies will be reviewed in this article.

参考文献/References:

[1] Rasey JS, Grierson JR, Wiens LW, et al. Validation of FLT uptake as a measure of thymidine kinase-1 activity in A549carcinoma cells[J]. J Nucl Med, 2002, 43(9):1210-1217.
[2] Wagner M, Seitz U, Neumaier B, et al. Evaluation of pyrimidine metabolising enzymes and in vitro uptake of 3’-[18F]fluoro-3’ deoxythymidine ([18F]FLT) in pancreatic cancer cell lines[J]. Eur J Nucl Med Mol Imaging, 2002, 29(9):1174-1181.
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[4] Dittmann H, Dohmen BM, Kehlbach R, et al. Early changes in[18F]FLT uptake after chemotherapy:an experimental study[J]. EurJ Nucl Med Mol Imaging, 2002, 29(11):1462-1469.
[5] Dittmann H, Dohmen BM, Paulsen F, et al.[18F] FLT PET for diagnosis and staging of thoracic tumours[J]. Eur J Nucl Med Mol Imaging, 2003, 30(10):1407-1412.
[6] Buck AK, Halter G, Schirrmeister H, et al. Imaging proliferation in lung tumors with PET:18F-FLT versus 18F-FDG[J]. J Nucl Med, 2003, 44(9):1426-1431.
[7] Buck AK, Schirrmeister H, Hetzel M, et al. 3’-deoxy-3’-[18F]fluorothymidine-positron emission tomography for noninvasive assessment of proliferation in pulmonary nodules[J].Cancer Res, 2002, 62(12):3331-3334.
[8] Vesselle H, Grierson J, Muzi M, et al. In vivo validation of 3’-deoxy-3’-[18F]fluorothymidine ([18F] FLT) as a proliferation imaging tracer in humans:correlation of[18F] FLT uptake by positron emission tumography with Ki-67 immunohistochemistry and fl
[9] Francis DL, Visvikis D, Costa DC, et al. Potential impact of[18F]3’-deoxy-3’-fluorothymidine versus[18F] fluoro-2-deoxy-D-glucose in positron emission tomography for colorectal cancer[J]. Eur J Nucl Med Mol Imaging, 2003, 30(7):988-994.
[10] Wagner M, Seitz U, Buck A, et al. 3’-[18F]fluoro-3’-deoxythymidine ([18F]-FLT) as positron emission tomography tracer for imaging proliferation in a murine B-Cell lymphoma model and in the human disease[J]. Cancer Res 2003, 63(10):2681-2687.
[11] Lu L, Samuelsson L, Bergstrom M, et al. Rat studies comparing 11C-FMAU, 18F-FLT, and 76Br-BrFU as prolifera-tion markers[J]. J Nucl Med, 2002, 43(12):1688-1698.

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备注/Memo

备注/Memo:
收稿日期:2003-11-22。
更新日期/Last Update: 1900-01-01