[1]王叙馥.放射性核素标记奥曲肽诊断小细胞肺癌的研究进展[J].国际放射医学核医学杂志,2003,27(1):11-13.
　WANG Xu-fu.Development of study on diagnosis of small cell lung cancer with radioisotope labeled octreotide[J].International Journal of Radiation Medicine and Nuclear Medicine,2003,27(1):11-13.
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放射性核素标记奥曲肽诊断小细胞肺癌的研究进展(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
27
期数:
2003年第1期
页码:
11-13
栏目:
核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Development of study on diagnosis of small cell lung cancer with radioisotope labeled octreotide
作者:
王叙馥
266003 青岛, 青岛大学医学院附属医院核医学科
Author(s):
WANG Xu-fu
Department of Nuclear Medicine, The Affiliated Hospital of Qingdao University, Shangdong Qingdao 266003, China
关键词:
放射性核素标记; 奥曲肽; 小细胞肺癌
Keywords:
radioisotope labeling; octreotide; small cell lung cancer
分类号:
R817.4
摘要:
小细胞肺癌是神经内分泌肿瘤,起源于APUD(胺前体摄取脱羧化)细胞。其细胞表面高水平表达SSTR(生长抑素受体)。奥曲肽是SST(生长抑素)的八肽类似物,它保留了SST类似的活性结构而且有更强的生物学效应和更长的生物半衰期,不易被降解。用放射性核素标记奥曲肽来诊断小细胞肺癌是一种较为理想的无创伤性检查方法。
Abstract:
Small cell lung cancer is neuroendocrine neoplasm and origins from APUD (amine precursor uptake decarboxylation) cell. Somatostatin receptors (SSTR) are highly expressed on the surface of tumor cell. Octreotide is an analogue of somatostatin consisting of 8 amino acids, which with a similar bioactive structure not only has stronger biologic effect and longer biologic half life but also is less susceptible to degradation. Tumor receptor imaging with isotope labeled octreotide is a suitable noninvasive technique in the diagnosis of small cell lung cancer.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2002-04-03。
作者简介:王叙馥(1976-),女,硕士研究生,主要从事肿瘤核医学的研究。
更新日期/Last Update: 1900-01-01