[1]罗全勇.MIBG及其衍生物的研究进展[J].国际放射医学核医学杂志,2002,26(5):216-219.
　LUO Quan-yong.The recent research progress of MIBG and its derivatives[J].International Journal of Radiation Medicine and Nuclear Medicine,2002,26(5):216-219.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
26
期数:
2002年第5期
页码:
216-219
栏目:
综述
出版日期:
1900-01-01

文章信息/Info

Title:
The recent research progress of MIBG and its derivatives
作者:
罗全勇
200233 上海, 上海市第六人民医院
Author(s):
LUO Quan-yong
Department of Nuclear Medicine, Shanghai Sixth People’s Hospital, Shanghai Jiaotong University Affiliated Sixth People’s Hospital, Shanghai 200233, China
关键词:
间碘苄胍; 神经内分泌肿瘤; 嗜铬细胞瘤; 神经母细胞瘤; 心肌交感神经
Keywords:
metaiodobenzylguanidine; neuroendocrine tumor; pheochromocytoma; neuroblastoma; myocardial sympathetic
分类号:
R594.8
摘要:
MIBG(间碘苄胍)是神经递质去甲肾上腺素的功能性类似物,其转运、潴留与释放机制均与去甲肾上腺素相似。放射性核素标记的MIBG及其衍生物既可用于嗜铬细胞瘤、神经母细胞瘤等神经嵴起源肿瘤的诊断与治疗,也可用于心肌交感神经显像,评估心肌交感神经元的完整性与功能。
Abstract:
MIBG (metaiodobenzylguanidine)is a functional analog of the neurotransmitter norepinephrine.It is trans-ported,stored and rel eased by a mechanism similar to that of norepinephrine.MIBG and its derivatives are useful radio-pharmaceutical for the clinical scintigraphy and treatment of neural crest tumors such as pheochromocytoma and neurob-lastoma.Also it is applicable for myocardial imaging in evaluating the integrity and function of my ocardial presynapse sympathetic neuron.

参考文献/References:

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[7] Maunoury C, Agostini D, Acar P, et al. Impairment of cardiac neuronal function in children dilated cardiomyopathy:an 123I-MIBG scintigraphic Study[J]. J Ncul Med, 2000, 41:400-404.
[8] Bengel FM, Barthel P, Matsunari I, et al. Kinetics of 123I-MIBG after acute myocardial infarction and reperfusion therapy[J]. J Nucl Med, 1999, 40:904-910.
[9] Sakata K, Shirotani M, Yoshida H, et al. Cardiac sympathetic nervous system in early essential hypertension assessed by 123I-MIBG[J]. J Nucl Med, 1999, 40:6-11.
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[11] Takatsu H, Nishida H, Matsuo H, et al. Cardiac sympathetic denervation from the early stage of Parkinson’s disease:clinical and experimental studies with radiolabelled MIBG[J]. J Nucl Med, 2000, 41(1):71-77.
[12] Druschky A, Hilz MJ, Platsch G, et al. Differentiation of Parkinson’s disease and multiple system atrophy in early disease stages by means of I-123-MIBG SPECT[J]. J Neurol Sci, 2000, 175(1):3-12.
[13] Reinhardt MJ, Jungling FD, Krause TM, et al. Scintigraphic differentiation between two forms of primary dysautonomia early after onset of autonomic dysfunction:value of cardiac and pulmonary iodine-123 MIBG uptake[J]. Eur J Nucl Med, 2000, 27(5):595-600.
[14] Owens J, Bolster AA, Prosser JE, et al. No-carrier-added 123I-MIBG:an initial clinical study in patients with phaeochromocytoma[J]. Nucl Med Commun, 2000, 21(5):437-440.
[15] Kuin A, Rutgers M, van der Valk MA, et al. Bioavailability and toxicity after oral administration of m-iodobenzylguanidine (MIBG)[J]. Br J Cancer, 1999, 79(5-6):802-806.
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备注/Memo

备注/Memo:
收稿日期:2001-03-16。
作者简介:罗全勇(1972-),男,四川隆昌人,主治医师,医学硕士,主要从事核素诊断与治疗的研究。
更新日期/Last Update: 1900-01-01