[1]孙苏平.SDF-1的生物学功能及在干/祖细胞归巢中的作用[J].国际放射医学核医学杂志,2001,25(6):272-273.
 SUN Su-ping.Biological function of SDF-1 and its role in homing of haemopoietic stem/progenitor cells[J].International Journal of Radiation Medicine and Nuclear Medicine,2001,25(6):272-273.
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SDF-1的生物学功能及在干/祖细胞归巢中的作用(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
25
期数:
2001年第6期
页码:
272-273
栏目:
综述
出版日期:
1900-01-01

文章信息/Info

Title:
Biological function of SDF-1 and its role in homing of haemopoietic stem/progenitor cells
作者:
孙苏平
200433 上海, 第二军医大学放射医学教研室
Author(s):
SUN Su-ping
Deparment of Radiation Medicine, Second Military Medical University, Shanghai 200433, China
关键词:
造血干/祖细胞SDF-1/CXCR4归巢
Keywords:
haemopoietic stem/progenitor cellsSDF-1/CXCR4homing
分类号:
R331.2
摘要:
造血干/祖细胞归巢的分子机制尚不清楚。近年来的研究发现,基质细胞来源的细胞因子或称为趋化蛋白SDF-1及其配体CXCR4参与了趋化造血干/祖细胞向骨髓的迁徙、与骨髓微血管内皮的粘附、穿内皮迁徙、与骨髓基质细胞粘附的归巢全过程,在干/祖细胞归巢过程中可能有关键性的作用。
Abstract:
The molecular mechanism of homing of haemopoietic stem/progenitor cells is beyond understanding.Recent years,however,it have been found that a chemokine or chemoat-tractant stromal cell-derived factor 1 (SDF 1) and its ligand CXCR4 receptor may involve in the process of transendothelial migration and adhere to bone marrow stromal cells.It may play key role in homing of haemopoietic stem/progenitor cells.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2001-4-2。
基金项目:国家自然科学基金项目(39770329;39600077)
作者简介:孙苏平(1956-),男,江苏徐州人,博士研究生,主要从事辐射损伤修复、恶性肿瘤放射治疗等方面的研究。
更新日期/Last Update: 1900-01-01