[1]魏利娟,李新,董华,等.天津市834名社区脑卒中高危人群血清同型半胱氨酸水平及相关危险因素分析[J].国际放射医学核医学杂志,2016,40(1):17-21.[doi:10.3760/cma.j.issn.1673-4114.2016.01.004]
　Wei Lijuan,Li Xin,Dong Hua,et al.Analysis of the serum homocysteine levels and the relevant risk factors of stroke on 834 high-risk community residents in Tianjin[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(1):17-21.[doi:10.3760/cma.j.issn.1673-4114.2016.01.004]
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天津市834名社区脑卒中高危人群血清同型半胱氨酸水平及相关危险因素分析(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
40
期数:
2016年第1期
页码:
17-21
栏目:
出版日期:
2016-01-25

文章信息/Info

Title:
Analysis of the serum homocysteine levels and the relevant risk factors of stroke on 834 high-risk community residents in Tianjin
作者:
魏利娟1;  李新2;  董华1;  董萍1;  张悦1;  焦妍1;  张遵城1
1. 300211, 天津医科大学第二医院核医学科;
2. 300211, 天津医科大学第二医院神经内科
Author(s):
Wei Lijuan1;  Li Xin2;  Dong Hua1;  Dong Ping1;  Zhang Yue1;  Jiao Yan1;  Zhang Zuncheng1
1. Department of Nuclear Medicine, the Second Hospital of Tianjin Medical University, Tianjin 300211, China;
2. Department of Neurology, the Second Hospital of Tianjin Medical University, Tianjin 300211, China
关键词:
脑血管意外; 危险因素; 高危人群; 血清同型半胱氨酸
Keywords:
Cerebrovascular accident; Risk factors; High-risk population; Serum homocystenine
DOI:
10.3760/cma.j.issn.1673-4114.2016.01.004
摘要:
目的 了解天津市河北区及东丽区40岁以上脑卒中高危人群危险因素、暴露水平及其人群分布特征,探讨脑卒中高危人群血清同型半胱氨酸(Hcy)水平及其影响因素。方法 纳入脑卒中高危人群834名,按年龄将其分为A组(40~49岁)、B组(50~59岁)、C组(60~69岁)和D组(≥70岁)。通过方差分析、χ2检验及二元logistic回归分析对数据进行分析。结果 A组血清Hcy水平为(12.25±4.54)μmol/L,B组为(14.01±6.67)μmol/L,C组为(15.76±8.88)μmol/L,D组为(18.21±8.99)μmol/L,随着年龄增长血清Hcy水平也随之升高(F=15.476,P<0.05)。男性高同型半胱氨酸血症(hhcy)比例高于女性(>χ2=31.034,P<0.05)。既往脑卒中史及吸烟者hhcy比例高于非暴露者(>χ2=9.888和18.486,P均<0.05);短暂性脑缺血发作、心脏病、高血压、血脂异常及缺乏体育锻炼者HHcy比例与非暴露者比较差异无统计学意义(χ2=0.688、0.773、2.042、1.427和0.560,P均>0.05);而糖尿病者HHcy比例低于非暴露者(χ2=30.345,P<0.05)。logistic回归分析得到hhcy的独立危险因素包括男性(or>结论 血清Hcy检测在脑卒中高危人群筛查中有重要价值,HHcy是脑卒中的独立危险因素之一。应对脑卒中高危人群进行科学的指导干预以降低脑卒中的发生率。undefinedundefinedundefined
Abstract:
Objective To identify the risk factors,level of exposure,and the population distribution in high-risk stroke people groups with age over 40 years in Hebei and Dongli Districts of Tianjin.To explore the level of serum homocystenine(Hcy) and its influencing factors.Methods A total of 834 high-risk cases were accepted and divided into groups A(40~49),B(50~59),C(60~69),and D(≥70) based on age.Data were analyzed using ANOVA,Chi-square test,and binary logistic regression.Results The serum Hcy values were(12.25±4.54),(14.01±6.67),(15.76±8.88),and(18.21±8.99)μmol/L for groups A to D,respectively.The level of serum Hcy increased with increasing age(F=15.476,P<0.05).The rate of males with hyperhomocysteinemia(HHcy) was significantly higher than that of females(χ2=31.034,P<0.05).The rates in the exposed group with previous stroke history and smoking were significantly higher than those of the non-exposed group(χ2=9.888 and 18.486,both P<0.05).The rates in exposed group with transient ischemic attack(TIA),heart disease,high blood pressure,dyslipidemia,and lack of physical exercise showed no significant difference with the non-exposed group(χ2=0.688,0.773,2.042,1.427 and 0.560,all P>0.05),but the rate in exposed group with diabetes was significantly lower than nonexposed group(χ2=30.345,P<0.05).The independent risk factors of HHcy were male(OR=2.332),smoking(OR=1.537),and previous stroke history(OR=1.946) according to the logistic regression.Conclusions The detection of serum Hcy is extremely important in screening high-risk populations for stroke.HHcy is an independent risk factor of stroke.It’s important to take measures to reduce the incidence of stroke.

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备注/Memo

备注/Memo:
收稿日期:2015-09-01;改回日期:。
通讯作者:张遵城
更新日期/Last Update: 1900-01-01