[1]郭莘,戴红峰,周硕,等.顶空毛细管气相色谱法测定18F-氟代乙酸盐中有机溶剂残留[J].国际放射医学核医学杂志,2015,39(6):458-461.[doi:10.3760/cma.j.issn.1673-4114.2015.06.005]
　Guo Shen,Dai Hongfeng,Zhou Shuo,et al.Determination of residual organic solvents in 18F-FAC by gas chromatography[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(6):458-461.[doi:10.3760/cma.j.issn.1673-4114.2015.06.005]
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
39
期数:
2015年第6期
页码:
458-461
栏目:
出版日期:
2015-11-25

文章信息/Info

Title:
Determination of residual organic solvents in 18F-FAC by gas chromatography
作者:
郭莘;  戴红峰;  周硕;  陈文新
350001, 福州, 福建省立医院核医学科PET/CT中心
Author(s):
Guo Shen;  Dai Hongfeng;  Zhou Shuo;  Chen Wenxin
Center of PET/CT, Department of Nuclear Medicine, Fujian Provincial Hospital, Fuzhou 350001, China
关键词:
氟醋酸盐类; 色谱法; 气相; 有机溶剂残留量
Keywords:
Fluoroacetates; Chromatography;  gas; Residual organic solvents
DOI:
10.3760/cma.j.issn.1673-4114.2015.06.005
摘要:
目的 建立以毛细管气相色谱法测定18F-氟代乙酸盐(18F-FAC)中乙腈、丙酮和乙醇3种有机溶剂残留量的方法。方法 采用HP-INNOWAX(30 m×0.53 mm,1 μm)毛细管色谱柱和氢火焰离子化检测器,检测器温度为270℃,进样口温度为200℃,柱温采用程序升温,载气为氮气,进样量为1 μl。结果 乙腈、丙酮和乙醇均能得到较好的分离,呈现良好的线性关系,相关系数分别为:0.9999、0.9973、0.9988,平均回收率分别为99.8%、101.0%、97.5%,相对标准偏差值分别为4.6 %、4.0%、1.5%。结论 毛细管气相色谱法简便快速、灵敏度高、结果准确可靠,适用于18F-FAC中残留有机溶剂的测定。
Abstract:
Objective To develop a method for residual organic solvent determination in 18F-fluoroacetate(18F-FAC) using capillary gas chromatography. Methods The residual organic solvents were separated on the HP-INNOWAX capillary chromatographic column using temperature programming. Nitrogen gas was used as the carrier gas, along with a flame ionization detector(FID). The FID and injector temperatures were 270℃ and 200℃, respectively, and the injection volume was 1 μl. Results Good linear relationships in the experimental concentrations(r=0.9999, 0.9973, 0.9988) were observed. The three residual organic solvents were separated completely; the average recoveries were 99.8%, 101.0%, and 97.5%, and the relative standard deviation values were 4.6%, 4.0%, and 1.5%, respectively. Conclusion The proposed method is simple, rapid, accurate, and highly sensitive, which can be used in detecting residual organic solvents in 18F-FAC.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2015-4-17。
基金项目:福建省卫生系统中青年骨干人才培养项目(2013-ZQN-JC-4)
通讯作者:陈文新,Email:wenxinchzt@aliyun.com
更新日期/Last Update: 1900-01-01