[1]冉曦,王明科,冉新泽,等.miRNAs在放射医学研究中的应用[J].国际放射医学核医学杂志,2015,39(4):332-335.[doi:10.3760/cma.j.issn.1673-4114.2015.04.013]
　Ran Xi,Wang Mingke,Ran Xinze,et al.MicroRNAs and their applications in radiation medicine[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(4):332-335.[doi:10.3760/cma.j.issn.1673-4114.2015.04.013]
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
39
期数:
2015年第4期
页码:
332-335
栏目:
出版日期:
2015-07-25

文章信息/Info

Title:
MicroRNAs and their applications in radiation medicine
作者:
冉曦1; 4;  王明科3;  冉新泽2;  王艾平1
1. 第三军医大学军事预防医学院全军复合伤研究所, 重庆, 400038;
2. 第三军医大学军事预防医学院创伤、烧伤与复合伤国家重点实验室, 重庆, 400038;
3. 海军医学研究所, 上海, 200433;
4. 第三军医大学新桥医院检验科, 重庆, 400037
Author(s):
Ran Xi1; 4;  Wang Mingke3;  Ran Xinze2;  Wang Aiping1
Institute of Combined Injury, School of Military Preventive Medicine, Third Military Medical University, Chongqing 400038, China
关键词:
微小RNAs; 放射医学; 辐射致癌; 辐射增敏; 辐射抗拒
Keywords:
MicroRNAs; Radiation medicine; Radiation carcinogenesis; Radiosensitivity; Radioresistance
DOI:
10.3760/cma.j.issn.1673-4114.2015.04.013
摘要:
microRNAs (miRNAs)是一类内源性的非编码RNA,通过与靶mRNA特异性的结合而导致靶mRNA降解或抑制其翻译,对基因进行转录后调控,进而影响各种生命活动。大量研究表明,miRNAs与辐射致癌效应、辐射增敏效应、肿瘤辐射抗拒和辐射旁效应密切相关,已成为放射医学研究的热点。笔者就miRNAs及其在放射医学研究中的应用作一综述。
Abstract:
MicroRNAs (miRNAs) are endogenous non-coding RNAs,which can degrade their target mRNAs or inhibit their translation by binding to their target mRNAs specifically.MiRNAs act as post-transcriptional regulators of gene expression,and then are involved in diverse physiological activities.Many studies has shown that miRNAs are closely related with radiation carcinogenesis,radiosensitivity,radioresistance and radiation-induced bystander effects,and have being a hotspot in radiation-medicine research.This review focuses on the introduction of miRNAs and their applications in radiation medicine.

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相似文献/References:

[1]郭丽,范洪学.干细胞在放射医学研究中的进展[J].国际放射医学核医学杂志,2003,27(2):80.
　GUO Li,FAN Hong-xue.The advancement of stem cells in radiation medicine[J].International Journal of Radiation Medicine and Nuclear Medicine,2003,27(4):80.

备注/Memo

备注/Memo:
收稿日期:2015-01-04。
基金项目:国家自然科学基金(项目编号:81172600,81272101)
通讯作者:王艾平,Email:waiping2012@163.com;冉新泽,Email:ranxinze@163.com
更新日期/Last Update: 1900-01-01