[1]李春星,李华,周仪,等.静息态功能磁共振成像技术对右侧小脑参与语言功能的应用研究[J].国际放射医学核医学杂志,2014,38(4):211-215.[doi:10.3760/cma.j.issn.1673-4114.2014.04.001]
　Li Chunxing,Li Hua,Zhou Yi,et al.Analysis of the mechanism of right cerebellum in language using resting state functional magnetic resonance imaging[J].International Journal of Radiation Medicine and Nuclear Medicine,2014,38(4):211-215.[doi:10.3760/cma.j.issn.1673-4114.2014.04.001]
点击复制

静息态功能磁共振成像技术对右侧小脑参与语言功能的应用研究(/HTML)
分享到：

《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
38
期数:
2014年第4期
页码:
211-215
栏目:
出版日期:
2014-07-25

文章信息/Info

Title:
Analysis of the mechanism of right cerebellum in language using resting state functional magnetic resonance imaging
作者:
李春星1;  李华2;  周仪1;  方艺1;  段婷婷1
1. 盐城市第一人民医院磁共振室, 224005;
2. 石河子大学医学院第三附属医院神经医学中心, 832000
Author(s):
Li Chunxing1;  Li Hua2;  Zhou Yi1;  Fang Yi1;  Duan Tingting1
Department of MRl, the First People’s Hospitd of Yancheng, Yancheng 224005, China
关键词:
小脑; 失语; 磁共振成像
Keywords:
Cerebellum; Aphasia; Magnetic resonance imaging
DOI:
10.3760/cma.j.issn.1673-4114.2014.04.001
摘要:
目的 通过静息态功能磁共振成像技术来探讨小脑在产生语言中的作用机制。方法 运用西门子3.0T磁共振仪获得静息态数据,用DPARSF软件对静息态数据进行预处理。首先对12例卒中后失语患者和20例正常对照者进行低频振荡振幅(ALFF)分析,在REST软件中行两样本t检验,得到失语组右侧小脑的某一脑区ALFF信号低于正常对照组,然后把此脑区作为种子点和ROI选取区,在正常对照组中进行单样本t检验,得到功能连接图。结果 与正常对照组相比,失语组左侧颞中回、左侧前额叶内侧回、右侧小脑的ALFF减低;右侧小脑在正常对照组功能连接的脑区有小脑蚓部、左侧颞中回、左侧额上回内侧面、辅助运动区。结论 右侧小脑本身及通过影响与其存在功能连接和解剖连接的脑区参与语言的产生。
Abstract:
Objective To elucidate the generation mechanism of cerebellum in language by resting state functional magnetic resonance imaging (fMRI).Methods Siemens verio 3.0T MR Scanner was used to obtain all of the subjects of fMRI data.The fMRI data were processed with the software of Data Processing Assistant for Resting-State fMRI Analysis Toolkit.Firstly,12 patients with poststroke aphasia and 20 normal controls were analyzed by amplitude of low frequency fluctuation (ALFF)and performed with two sample t-test by REST software; Secondly,decreased ALFF of certain brain regions of the cerebellum were selected as the regions of seed point and ROI,and then calculated the single sample t-test in normal controls to obtain function connectivity map.Results As compared with those in normal subjects,the regions showing decreased ALFF in aphasia patients were distributed in left middle temporal gyrus,left medial prefrontal gyrus,fight cerebellum.Positive functional connectivity with certain brain regions of the cerebellum ROI was seen in cerebellum tonsil,left middle temporal gyrus,left medial superior frontal gyrus and supplementary motor area.Conclusion Right cerebellum itself and through its impact on the presence of functional connections and structural connections of the brains participate in language production.

参考文献/References:

[1] 揭冰,杨振燕,赵小虎,等.小脑汉字词语处理相关脑区的功能磁共振研究[J].中国医学计算机成像杂志,2008, 14(3):200-204.
[2] James R, Booth, Lydia Wood, et al. The role of the basal ganglia and cerebellum in language processing[J]. Brain Res, 2007, 1133(1):136-144.
[3] 王荫华.西方失语证成套测验(WAB)介绍(-)[J].中国康复理论与实践杂志,1997,3(2):87-89.
[4] Logothetis NK, Pauls J, Augath M, et al. Neurophysiological investigation of the basis of the fMRI signal[J]. Nature, 2001,412(6843):150-157.
[5] Nir Y, Mukamel R, Dinstein I, et al. Interhemispheric correlations of slow spontaneous neuronal fluctuations revealed in human sensory cortex[J].Nat Neurosci, 2008, 11(9):1100-1108.
[6] Cao X, Cao Q, Long X, et al. Abnormal resting-state functional connectivity patterns of the putamen in medication-naive children with attention deficit hyperactivity disorder[J]. Brain Res, 2009, 1303:195-206.
[7] Silveri MC, Misciagna S. Language, memory, and the cerebellum[J]. J Neurolinguistics, 2000, 13(2):129-143.
[8] Mari?:n P, Baillieux H, De Smet HJ, et al. Cognitive, linguistic and affective disturbances following a right superior cerebellar artery infarction:a case study[J]. Cortex, 2009, 45 (4):527-536.
[9] Murdoch BE. The cerebellum and language:historical perspective and review[J]. Cortex, 2010, 46(7):858-868.
[10] Dronkers NF, Wilkins DP, Van Valin RD Jr, et al. Lesion analysis of the brain areas involved in language comprehension[J]. Cognition, 2004, 92 (1-2):145-177.
[11] Turken AU, Dronkers NF. The neural architecture of the language comprehension network:converging evidence from lesion and connectivity analyses[J]. Front Syst Neurosci, 2011, 5:1.
[12] Krainik A, Lehé:ricy S, Duffau H, et al. Postoperative speech disorder after medial frontal surgery:role of the supplementary motor area[J]. Neurology, 2003, 60(4):587-594.
[13] Alexander GE, Crutcher MD, DeLong MR. Basal ganglia-thalamocortical circuits:parallel substrates for motor, oculomotor, "prefrontal" and "limbic" functions[J]. Prog Brain Res, 1990, 85:119-146.
[14] Gold M, Nadesu SE, Jacobs DH, et al. Adynamic aphasia:A transcortical motor aphasia with defective semantic strategy formation[J]. Brain Lang, 1997, 57(3):374-393.

备注/Memo

备注/Memo:
收稿日期:2013-11-22。
基金项目:国家自然科学基金(31260235)
通讯作者:李华(Email:Lh-shzpd@126.com)
更新日期/Last Update: 1900-01-01