[1]王营营,周道洪,孟爱民.前列腺素E2对造血干细胞的调控作用研究进展[J].国际放射医学核医学杂志,2013,37(5):292-295.[doi:10.3760/cma.j.issn.1673-4114.2013.05.010]
　WANG Ying-ying,ZHOU Dao-hong,MENG Ai-min.Prostaglandin E2 regulates hematopoietic stem cell[J].International Journal of Radiation Medicine and Nuclear Medicine,2013,37(5):292-295.[doi:10.3760/cma.j.issn.1673-4114.2013.05.010]
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
37
期数:
2013年第5期
页码:
292-295
栏目:
综述
出版日期:
2013-09-25

文章信息/Info

Title:
Prostaglandin E2 regulates hematopoietic stem cell
作者:
王营营;  周道洪;  孟爱民
300192 天津, 北京协和医学院中国医学科学院放射医学研究所, 天津市分子核医学重点实验室
Author(s):
WANG Ying-ying;  ZHOU Dao-hong;  MENG Ai-min
Tianjin Key Laboratory of Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin 300192, China
关键词:
地诺前列酮; 造血干细胞; 造血系统稳态
Keywords:
Dinoprostone; Hematopoietic stem cells; Hematopoietic homeostasis
DOI:
10.3760/cma.j.issn.1673-4114.2013.05.010
摘要:
前列腺素E2(PGE2)是一种不饱和脂肪酸,具有多种生理活性,由环氧合酶(COX)在炎症刺激下合成。PGE2能抑制髓系祖细胞分化,促进红系祖细胞增生,对造血系统有着重要的调节作用,近期研究发现用PGE2增加造血干细胞(HSC)数量,体外可以减少HSC的凋亡,提高HSC的长期移植重建能力和归巢能力,提示PGE2对HSC有重要的调控作用。此外,PGE2还可以增强辐射损伤后HSC造血系统的重建能力,维持造血系统的稳定性。PGE2调节HSC机制的研究表明,PGE2可以通过抑制活性氧自由基的产生来防止HSC的过度分化,另外还可以通过Wnt信号通路起到维持HSC稳态的作用。将经PGE2处理后的脐带血移植到灵长类动物体内已被证实是安全的,预示着PGE2在骨髓移植中有着潜在的重要临床意义。该文将对最近几年PGE2对HSC的调控作用的相关研究进行综述。
Abstract:
Prostaglandin E2 (PGE2)is a bioactive lipid molecule produced by cyclooxygenase (COX), which plays an important role on hematopoiesis.While it can block differentiation of myeloid progenitors but enhance proliferation of erythroid progenitors.Recent research found that PGE2 have the effects on hematopoietic stem cell(HSC) function and these effects were independent from effects on progenitor cells.Exposure of HSC cells to PGE2 in vitro can increase homing efficiency of HSC to the murine bone marrow compartment and decrease HSC apoptosis, meanwhile increase long-term stem cell engraftment.In-vivo treatment with PGE2 expands short-term HSC and engraftment in murine bone marrow but not long-term HSC.In addition, PGE2 increases HSC survival after radiation injury and enhance hematopoietic recovery, resulting maintains hematopoietic homeostasis.PGE2 regulates HSC homeostasis by reactive oxygen species and Wnt pathway.Clinical beneficial of 16, 16-dimethyl-prostaglandin E2 treatment to enhance engraftment of umbilical cord blood suggest important improvements to therapeutic strategies.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2013-03-18。
基金项目:国家重大科学计划(2011CB964800-G);国家自然科学基金(81072237,81129020);天津市应用基础及前沿技术研究计划(11JCZDJC19100);教育部高等学校博士学科点专项基金(20111106110038)
通讯作者:孟爱民,Email:aiminmeng@irm.cams.ac.cn
更新日期/Last Update: 1900-01-01