[1]袁超,李卫鹏.99Tcm-tetrofosmin:一种评价体内P-糖蛋白功能变化的显像剂[J].国际放射医学核医学杂志,2009,33(3):144-148.[doi:10.3760/cma.j.issn.1673-4114.2009.03.005]
 YUAN Chao,LI Wei-peng.99Tcm-tetrofosmin: a functional imaging agent of evaluation P-glycoprotein modulation in vivo[J].International Journal of Radiation Medicine and Nuclear Medicine,2009,33(3):144-148.[doi:10.3760/cma.j.issn.1673-4114.2009.03.005]
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
33
期数:
2009年第3期
页码:
144-148
栏目:
核医学诊断
出版日期:
1900-01-01

文章信息/Info

Title:
99Tcm-tetrofosmin: a functional imaging agent of evaluation P-glycoprotein modulation in vivo
作者:
袁超 李卫鹏
安徽省蚌埠医学院第一附属医院核医学科, 安徽 233004
Author(s):
YUAN Chao LI Wei-peng
Department of Nuclear Medicine, The First Affiliated Hospital of Bengbu Medical College, Bengbu, 233004, China
关键词:
Tetrofosmin抗药性多药肿瘤体层摄影术发射型计算机单光子P-糖蛋白
Keywords:
TetrofosminDrug resistancemultipleNeoplasmsTomographyemission-computedsingle-photonP-glyeoprotein
DOI:
10.3760/cma.j.issn.1673-4114.2009.03.005
摘要:
99Tcm-tetrofosmin是一种制备简便、使用广泛的显像剂,在体内和体外它均为多药耐药蛋白和P-糖蛋白转运的底物。它的特点与99Tcm-甲氧基异丁基异腈(99Tcm-MIBI)相似但不完全一样。现有的文献提示,有关多药耐药性功能显像和体内多药耐药性功能调节的临床研究可以通过99Tcm-tetrofosmin和99Tcm-MIBI显像来进行,但是两者似乎不能互换。
Abstract:
99Tcm-tetrofosmin is a widely available and conveniently prepared tracer that has been shown to be a transport substrate for P-glycoprntein and multidrug resistance protein in vitro and in vivo. Its properties are similar but not identical to those of 99Tcm-sestamibi. The available data suggest that clinical studies involving imaging of muhidrug resisttanee function and in vivo modulation of muhidrug resisttance function could be performed with 99Tcm-tetrofosmin or 99Tcm-sestamibi, but the two should probably not be used interchangeably.

参考文献/References:

[1] Georgoulias P, Tzavara C, Demakopoulous N, et al. Incremental prognostic value of 99mTc-tetrofosmin myocardial SPECT after percutaneous coronary intervention. Ann Nucl Med, 2008, 22(10):899-909.
[2] Alexiou GA, Tsiouris S, Kyritsis AP, et al. 99mTc-Tetrofosmin SPECT for the detection of glioma recurrence. Eur J Nucl Med Mol Imaging, 2008, 35(8):1571-1572.
[3] Spanu A, Cottu P, Manca A, et al. Scintimammography with dedicated breast camera in unifocal and multifocal/multicentric primary breast cancer detection:a comparative study with SPECT. Int J Oncol, 2007, 31(2):369-377.
[4] 陈慧玲,白海.肿瘤多药耐药的研究进展.临床肿瘤学杂志,2008,13(5):475-477.
[5] Abaan OD, Mutlu PK, Baran Y, et al. Muhidrug resistance mediated by MRPI gene overexpression in breast cancer patients. Cancer Invest, 2009, 27(2):201-205.
[6] Haslam IS, Jones K, Coleman T, et al. Induction of P-glycoprotein expression and function in human intestinal epithelial cells (T84). Biochem Pharmacol, 2008, 76(7):850-861.
[7] Takahashi K, Shibata T, Oba T, et al. Muhidrug-resistance-associated protein plays a protective role in menadione-induced oxidative stress in endothelial cells. Life Sci, 2009, 84(7-8):211-217.
[8] Odening KE, Li W, Rutz R, et al. Enhanced complement resistance in drug-selected P-glycoprotein expressing multi-drug-resistant ovarian carcinoma cells. Clin Exp hnmunol, 2009, 155(2):239-248.
[9] Schmidt M, Teitge M, Castillo ME, et al. Synthesis and biochemical characterization of new phenothiazines and related drugs as MDR reversal agents. Arch Pharm(Weinhemin), 2008, 341(10):624-638.
[10] Morschhauser F, Zinzani PL, Burgess M, et al. Phase I/II trial of a P-glycoprotein inhibitor, Zosuquidar. 3HC1 trihydrochloride (LY335979), given orally in combination with the CHOP regimen in patients with non-Hodgkin’s lymphoma. Leuk Lymphoma, 2007, 48(4):708-715.
[11] Bihorel S, Camenisch G, Lemaire M, et al. Modulation of the brain distribution of imatinib and its metabolites in mice by valspodar, zosuquidar and elacridar. Pharm Res, 2007, 24(9):1720-1728.
[12] Carlson RW, O’Neill AM, Goldstein L J, et al. A pilot phase II trial of valspodar modulation of multidmg resistance to paclitaxel in the treatment of metastatic carcinoma of the breast (E1195):a triat of the Eastern Cooperative Oncology Group. Cancer Invest, 2006, 24(7):677-681.
[13] Péréz-Tomás. Multidrug resistance:retrospect and prospects in anti-cancer drug treatment. Curr Med Chem, 2006, 13(16):1859-1876.
[14] Utsunomiya K, Ballinger JR, Piquette-Miller M, et al. Comparison of the accumulation and efflux kinetics of technetium-99msestamibi and technetium-99mtetrofosmin in an MRP-expressing tumor cell line. Eur J Nucl Med, 2000, 27(12):1786-1792.
[15] Dorajoo R, Pereira BP, Yu Z, et al. Role of multi-drug resistanceassociated protein-1 transporter in statin-induced myopathy. Life Sci, 2008, 82(15-16):823-830.
[16] Lewis-Wambi JS, Kim HR, Wambi C, et al. Buthionine sulfoximine sensitizes antihormone-resistant human breast cancer cells to estrogen-induced apoptosis. Breast Cancer Res, 2008, 10(6):R104.
[17] Bankstahl JP, Kuntner C, Abrahim A, et al. Tariquidar-induced P-glycoprotein inhibition at the rat blood-brain barrier studied with (R)-11C-verapamil and PET. J Nucl Med, 2008, 49(8):1328-1335.
[18] Kurdziel KA, Kalen, JD, Hirsch JI, et al. Imaging muhidrug resistance with 4-[18F]fluoropaclitaxel. Nucl Med Biol, 2007, 34(7):823-831.
[19] Yang A, Xue J, Li X, et al. Experimental and clinical observations of 99mTc-MIBI uptake correlate with P-glyeoprotein expression in lung cancer. Nucl Med Commun, 2007, 28(9):696-703.
[20] Burak Z, Moretti JL, Ersoy O, et al. 99mFc-MIBI imaging as a predictor of therapy respose in osteosarcoma compared with multidrug resistance-associated protein and P-glycoprotein expression. J Nucl Med, 2003, 44(9):1394-1401.
[21] Elhendy A, Schinkel AF, van Domberg RT, et al. Non-invasive diagnosis of in stent stenosis by stress 99m technetium tetrofosmin myocardial perfusion imaging. Int J Cardiovasc Imaging, 2006, 22(5):657-662.
[22] Younès A, Songadele JA, Maublant J, et al. Mechanism of uptake of technetium-tetrofosmin. II:Uptake into isolated adult rat heart mitochondria. J Nucl Cardiol, 1995, 2(4):327-333.
[23] Piwnica-Worms D, Chiu ML, Budding M, et al. Functional imaging of muhidrug-resistant P-glycoprotein with an organotechnetium complex. Cancer Res,1993, 53(5):977-984.
[24] Ballinger JR, Bannerman J, Boxen I, et al. Technetium-99m-tetrofosmin as a substrate for P-glyeoprotein:in vitro studies in multidrug-resistant breast tumor cells. J Nucl Med, 1996, 37(9):1578-1582.
[25] Liu Z, Stevenson GD, Barrett HH, et al. Imaging recognition of inhibition of multidrug resistance in human breast eaneer xenografts using 99mTc-labeled sestamibi and tetrofosmin.Nncl Med Biol, 2005, 32(6):573-583.
[26] Chen WS, Luker KE, Dahlheimer JL, et al. Effects of MDR1 and MDR3 P-glycoproteins, MRPI, and BCRP/MXR/ABCP on the transport of 99mTc-tetrofosmin. Biochem Pharmacol, 2000, 60(3):413-426.
[27] Soderlund V, Jonsson C, Bauer HC, et al. Comparison of technetium-99m-MIBI and technetium-99m-tetrofosmin uptake by musculoskeletal sarcomas. J Nucl Med,1997, 38(5):682-686.
[28] Mansi L, Rambaldi PF, Cuccurullo V, et al. Diagnostic and prognostic role of 99mTc-tetrofosmin in breast cancer. Q J Nutl Med, 1997, 41(3):239-250.
[29] Sun SS, Hsieh JF, Tsai SC, et al. Technetium-99m tetrofosmin mammoscintigraphy findings related to the expression of P-glycoprotein mediated multidrug resistance. Anticancer Res, 2000, 20(3A):1467-1470.

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备注/Memo

备注/Memo:
收稿日期:2009-01-04
通讯作者:袁超,E-mail:ychsysu@yahoo.com.cn
更新日期/Last Update: 1900-01-01