[1]瞿跃进,俞浩,陈贵兵,等.血浆脑利钠肽在快速鉴别诊断心源性和肺源性呼吸困难中的价值[J].国际放射医学核医学杂志,2008,32(4):218-220.
　QU Yue-jin,YU Hao,CHEN Gui-bing,et al.Value of plasma brain natriuretie peptide for differentiating cardiogenic dyspnea from pulmogenic dyspnea[J].International Journal of Radiation Medicine and Nuclear Medicine,2008,32(4):218-220.
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血浆脑利钠肽在快速鉴别诊断心源性和肺源性呼吸困难中的价值(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
32
期数:
2008年第4期
页码:
218-220
栏目:
临床核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Value of plasma brain natriuretie peptide for differentiating cardiogenic dyspnea from pulmogenic dyspnea
作者:
瞿跃进1;  俞浩2;  陈贵兵2;  方亚3;  黄劲雄2;  何小江2
1. 361003 厦门, 厦门市第一医院呼吸内科;
2. 361003 厦门, 厦门市第一医院核医学科;
3. 361003 厦门, 厦门大学侠学院预防医学系
Author(s):
QU Yue-jin1;  YU Hao2;  CHEN Gui-bing2;  FANG Ya3;  HUANG Jin-xiong2;  HE Xiao-jiang2
1. Department of Respiratory Medicine, Fujian Medical University, Xianmen, Fujian 361003, China;
2. Department of Nuclear Medicine, FiLet Hospital of Xiamen, Fujian Medical University, Xianmen, Fujian 361003, China;
3. Department of Phylaxiology, Me
关键词:
呼吸困难; 利钠肽; 脑; 心室功能障碍; 左
Keywords:
Dyspnea; Natriuretic peptide; brain; Ventricular dysfunction; left
摘要:
目的 评价血浆脑利钠肽(BNP)水平在心源性和肺源性呼吸困难时鉴别诊断的价值。方法 采用美国拜尔公司生产的化学发光检测仪及其BNP试剂,检测248例因呼吸困难住院的肺疾病患者血浆BNP水平,对单纯肺疾病患者、肺疾病并发左心功能不全患者、肺疾病未并发左心功能不伞患者、肺疾病并发右心衰患者各组间BNP水平进行比较。结果 肺疾病并发左心功能不全的呼吸困难患者的BNP水平明显高于未并发左心功能不全的呼吸困难患者(χ2=25.597,P<0.001);肺疾病并发右心衰患者BNP水平高于单纯肺疾病患者,但差异没有统计学意义(t=1.614,P>0.05);肺疾病并发左心功能不全患者的BNP水平明显高于肺疾病并发右心衰患者(t=2.531,P<0.05);肺疾病并发左心功能不全患者的心功能越差,BNP水平就越高,心功能Ⅱ、Ⅲ、Ⅳ级三组间BNP水平的差别有统计学意义(χ2=29.463,P<0.001)。结论 血浆BNP是快速鉴别诊断心源性和肺源性呼吸困难的莺要实验室检测指标,同时可判断肺疾病并发左心功能不全患者心衰的严重程度。
Abstract:
Objective To evaluate the value of plasma brain natriuretic peptide (BNP) level for differentiating eardiogenie dyspnea from pulmogenic dyspnea.Methods The detection of plasma BNP was carried out in 248 patients with dyspnea.The apparatus was the CENTUR type chemiluminescence detection produced by the Bayer companies of USA.All patients were divided into three groups depending on disease severity.The level of plasma BNP in each group wag compared.Results The level of plasma BNP in pulmonary disease complicated with left ventricular dysfunction was higher than that of pulmonary disease non-complicated with left ventricular dysfunction.There was significant difference between two groups (χ2=25.597,P<0.001).The level of plasma BNP in pulmonary disease complicated with right ventricular dysfunction was higher than that of simple pulmonary disease.There was no significant difference between two groups (t=1.614,P>0.05).The level of plasma BNP in pulmonary disease complicated with left ventricular dysfunction was higher than that of pulmonary disease complicated with fight ventricular dysfunction.There Was significant difference between two groups (t=2.53 l,P<0.05).If the left ventricular dysfunction degree was notable,the level of plasma BNP waft,high.There was also significant difference in different cardiac function classification by New York Heart Association (χ2=29.463,P<0.001).Conclusion Plasma BNP analysis is an impotent method for differentiating cardiogenic dyspnea from pulmogenie dyspnea.Meanwhile,it is also helpful to evaluating the severity of pulmonary disease complicated with left ventricular dysfunction.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2008-04-01。
通讯作者:俞浩,E-mail:yuha060@gmail.com
更新日期/Last Update: 1900-01-01