[1]孙文钊,张良安.硼中子俘获治疗的微剂量学研究现状[J].国际放射医学核医学杂志,2007,31(1):61-63.
　SUN Wen-zhao,ZHANG Liang-an.The current status of the microdosimetry study of boron neutron capture therapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2007,31(1):61-63.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
31
期数:
2007年第1期
页码:
61-63
栏目:
医用内照射剂量
出版日期:
1900-01-01

文章信息/Info

Title:
The current status of the microdosimetry study of boron neutron capture therapy
作者:
孙文钊;  张良安
300192 天津, 中国医学科学院中国协和医科大学放射医学研究所保健物理研究室
Author(s):
SUN Wen-zhao;  ZHANG Liang-an
Department of Healthy Physics, Institute of Radiation Medicine, Chinese Academy of Medical Sicences and Peking Union Medical College, Tianjin 300192, China
关键词:
中子俘获疗法; 硼; 辐射剂量; 治疗; 计算机辅助
Keywords:
Neutron capture therapy;  born; Radiometry; Therapy;  computer-assisted
分类号:
R144.1
摘要:
微剂量学研究在临床硼中子俘获治疗(BNCT)的计划设计和疗效评价中起着重要作用。设计一套既能准确描述10B化合物及其反应产生的次级粒子在细胞、亚细胞水平的剂量不均匀分布,又适合于临床上使用的微剂量估算模式,一直是此领域的研究重点。为此,着重介绍了BNCT的微剂量估算方法及其最近发现显著影响其精确度的因素。
Abstract:
Microdosimetry plays an important role in the clinical application of boron neutron capture therapy (BNCT). There is increasing interest to develop a set of microdosimetry model, which can exactly describe the nonuniformly distribution of dose at cellar or sub-cellar level as well as conveniently used in clinic. In this paper, will give emphasis to the introduction of some common methods of microdosimtry and some affective factors reported in current reseaches on BNCT.

参考文献/References:

1 Tooru K, Yoshinori S, Masayori I. A noninvasive dose estimation system for clinical BNCT based on PG-SPECT-conceptual study and fundamental experiments using HPGe and CdTe semiconductor detectors. Med Phys, 2000, 27(9):2124-2131.
2 田源,张良安.放射免疫治疗中的核素微剂量研究.国际放射医学核医学杂志,2006,30(1):39-41.
3 Tung CJ, Liu CS, Wang JP, et al. Calculation of cellar microdosimetry parameter for alpha particles and electrons. Appl Radiat Isot, 2004, 61(5):739-743.
4 Rassow J, Sauerwein W, Wittig A, et al. Advantage and limitations of weighting factors and weighted dose quantities and their units in boron neutron capture therapy. Med Phys, 2004, 31(5):1128-1134.
5 Nievaart VA, Moss RL, Kloosterman JL, et al. A parameter study to determine the optimal source neutron energy in boron neutron capture therapy of brain tumours. Phys Med Biol, 2004, 49(18):4277-4292.
6 Santa Cruz GA, Zamenhof RG. The microdosimetry of the (10)B reaction in boron neutron capture therapy:a new generalized theory. Radiat Res, 2004, 162(6):702-710.
7 Kalend AM, Bloomer WD, Epperly MW. Dosimetric consequences of 10B (n, α)7Li reaction occurring at the celluar membrane.Int J Radiat Oncol Biol Phys, 1995, 31(1):171-178.
8 Kobayashi T, Kanda K. Analytical calculation of boron-10 dosage in cell nucleus for boron neutron capture therapy. Radiat Res, 1982,91(2):77-94.
9 Nichols TL, Miller LF, Kabalka GW. The microdosimetry of boron neutron capture therapy in a randomised ellipsoidal cell geometry.Radiat Prot Dosimetry, 2005, 116(2):466-469.
10 Gabel D, Foster S, Fairchild RG. The monte carlo simulation of the biological effect of the 10B (n,α)7Li reaction in ceils and tissues and its implication for boron neutron capture therapy. Radiat Res,1987, 111(1):14-25.
11 van Vliet-Vroegindeweij C, Wheeler F, Stecher-Rasmussen F, et al.Microdosimetry model for boron neutron capture therapy:Ⅰ. Determination of microscopic quantities of heavy particles on a cellular scale. Radiat Res, 2000, 155(3):490-497.

相似文献/References:

[1]向剑,戴光复,苑淑渝,等.中子剂量测量及估算方法[J].国际放射医学核医学杂志,2008,32(1):59.
　XIANG Jian,DAI Guang-fu,YUAN Shu-yu,et al.The measurement and calculation method for neutron dose[J].International Journal of Radiation Medicine and Nuclear Medicine,2008,32(1):59.

备注/Memo

备注/Memo:
收稿日期:2006-06-04。
通讯作者:张良安,E-mail:zhangla43@yahoo.com.cn
更新日期/Last Update: 1900-01-01