[1]王军英,涂彧,周菊英.放射性肺损伤防治措施研究进展[J].国际放射医学核医学杂志,2006,30(5):304-307.
 WANG Jun-yin,TU Yu,ZHOU Ju-ying.The progress in prevention and treatment of radiation-induced lung injury[J].International Journal of Radiation Medicine and Nuclear Medicine,2006,30(5):304-307.
点击复制

放射性肺损伤防治措施研究进展(/HTML)
分享到:

《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
30
期数:
2006年第5期
页码:
304-307
栏目:
放射生物学
出版日期:
1900-01-01

文章信息/Info

Title:
The progress in prevention and treatment of radiation-induced lung injury
作者:
王军英1 涂彧1 周菊英2
1. 215006 苏州, 苏州大学放射医学与公共卫生学院放射卫生室;
2. 215006 苏州, 苏州大学附属第一医院放疗科
Author(s):
WANG Jun-yin1 TU Yu1 ZHOU Ju-ying2
1. Department of Radiation Hygiene, College of Radiation Medicine and Public Health, Suzhou University, Suzhou 215006, China;
2. Department of Radiation Oncology, The First Hospital Affiliated to Suzhou University, Jiangsu Suzhou 215006, China
关键词:
辐射性肺炎肺纤维化辐射损伤
Keywords:
RadiaUon pheumonitisPulmonary fibrosisRadiation injuries
分类号:
R818.05
摘要:
放射性肺损伤是核辐射事故、骨髓移植预处理及胸部肿瘤放疗常见的并发症。糖皮质激素常被用于减轻放射性肺损伤的症状,但疗效并不理想。许多学者致力于评估一些防治措施在减轻辐射所致动物和人肺损伤的作用。本文就其研究进展进行综述,以期阐明防治现状,并在一定程度上对临床有所帮助。
Abstract:
Radiation-induced lung injury is a well-described complication of nuclear accidents, marrow-transplanted pretreatment, thoracic radiotherapy. Corticosteroid has been routinely employed to reduce the irradiation-induced lung injure, but has been demonstrated only marginal efficacy. Many researchers are addicted to research in this field, several preventions and treatments have been evaluated for their ability to reduce radiation-induced lung injury in animals and humans. Clarifying the research status and assisting the clinic at a certain extent are the aim of this article.

参考文献/References:

1 Anscher MS,Kong FM,Marks LB,et al.Changes in plasma transforming growth factor beta during radiotherapy and the risk of symptomatic radiation-induced pneumonitis.Int J Radiat Oncol Biol Phys,1997,37(2):253-258.
2 Vujaskovic Z,Groen HJM.TGF-[beta],radiation-induced pulmonary injury and lung cancer.Int J Radiat Biol Phys,2000,76(2):511-516.
3 Rübea CE,Wilferta F,Danielab U,et al.Modulation of radiationinduced tumour necrosis factor α (TNF-α) expression in the lung tissue by pentoxifylline.Radiat Oncol,2002,64(1):177-187.
4 Ozturk B,Egehan I,Atavci S,et al.Pentoxifylline in protection of radiation-induced lung toxicity in patients with breast and lung cancer:a double-blind randomized trial.Int J Radiat Oncol Biol Phys,2004,58(3):213-219.
5 Kawashima M,Yatsunam J,Fukuno Y,et al.Inhibitory effects of 14-membered ring macrolid antibiotics on bleomycin-induced acute lung injury.Lung,2002,180(2):73-89.
6 Kenneth M.Hemodynamic effect of PGE in patients with congential heart disease and pulmonary hypertension.Cathert Cardiovasc Diagn,1991,24(4):10.
7 Giris N.Effect of antibody to transforming growth factor β on bleomycin induced accumulation of lung collagen in mice.Thorax,1993,48(6):959-966.
8 Rabbani ZN,Anscher MS,Zhang X,et al.Soluble TGF-beta type Ⅱ receptor gene therapy ameliorates acute radiation-induced pulmonary injury in rats.Int J Radiat Oncol Biol Phys,2003,57(2):563-572.
9 Douglas WW,Ryu JH,Schroeder DR.Idiopsthic pulmonary fibrosis impact of oxygen and colchines,prednisone,or no therapy on survival.Am J Respir Crit Care Med,2000,161(4):1172-1178.
10 Joseph AL,Luis AO.Antifibrotic therapy for the treatment of pulmonary fibrosis.Am J Med Sci,2001,322(5):213-221.
11 Antonadou D,Petridis A,Synodinou M,et al.Amifostine reduces radiochemotherapy-induced toxicities in patients with locally advanced non-small cell lung cancer.Semin Oncol,2003,30(6 Suppl 18):2-9.
12 Neal R,Matthews RH,Lutz P,et al.Antioxidant role of Nacetyl cysteine isomers following high dose irradiation.Free Radic Biol Med,2003,34(6):689-695.
13 Epperly MW,Guo HL,Jeferson M,et al.Cell phenontype specific kinetics of expression of intratracheally injected manganese superoxide dismutase-plasmid/liposomes (MnSOD-PL) during lung radioprotective gene therapy.Gene Ther,2003,10(2):163-171.
14 Vujaskovic Z,Batinic-haberle I,Rabbani ZN,et al.A small molecular weight catalytic metalloporphyrin antioxidant with superoxide dismutase (SOD) mimetic properties protects lungs from radiation-induced injury.Free Radic Biol Med,2002,33(6):857-863.
15 Senner G,Jahovic N,Tosun O,et al.Melation a melerates ionizing radiation-induced oxidative organ damage in rats.Life Sci,2003,74(5):563-572.
16 Molteni A,Moulder J E,Cohen EF,et al.Control of radiation induced pneumopathy and lung fibrosis by angiotensin-converting enzyme inhibitors and angiotensin Ⅱ type 1 receptor blocker.Int J Radiat Biol Phys,2000,76(4):523-532.
17 段玉龙,范向辉,侯俊卿,等.艾迪注射液治疗放射性肺炎的疗效观察.中国中西医结合杂志,2004,24(3):256-257.

相似文献/References:

[1]李景涛,邓垒,张文珏,等.广泛期小细胞肺癌胸部IMRT后发生放射性肺炎的危险因素分析[J].国际放射医学核医学杂志,2016,40(2):100.[doi:10.3760/cma.j.issn.1673-4114.2016.02.003]
 Li Jingtao,Deng Lei,Zhang Wenjue,et al.Risk factor analysis for predicting radiation pneumonitis in extensive stage small cell lung cancer patients receiving IMRT thoracic radiotherapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(5):100.[doi:10.3760/cma.j.issn.1673-4114.2016.02.003]

备注/Memo

备注/Memo:
收稿日期:2006-04-04。
通讯作者:涂或,E-mail:tuyu@suda.edu.cn
更新日期/Last Update: 1900-01-01