[1]蔡迅,黄成文,黄仲良.连续性血液净化治疗顽固性心力衰竭患者35例结果分析[J].国际放射医学核医学杂志,2006,30(5):293-295.
　CAI Xun,HUANG Cheng-wen,HUANG Zhong-liang.Analyse in the patients with refractory heart purification treated by continuous blood purification[J].International Journal of Radiation Medicine and Nuclear Medicine,2006,30(5):293-295.
点击复制

连续性血液净化治疗顽固性心力衰竭患者35例结果分析(/HTML)
分享到：

《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
30
期数:
2006年第5期
页码:
293-295
栏目:
临床核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Analyse in the patients with refractory heart purification treated by continuous blood purification
作者:
蔡迅;  黄成文;  黄仲良
516001 广东惠州, 广东省惠州市中心人民医院肾内科
Author(s):
CAI Xun;  HUANG Cheng-wen;  HUANG Zhong-liang
Department of Kidney Medicine, Huizhou Center Hospital, Guangdong Huizhou 516001, China
关键词:
血液滤过; 顽固性心力衰竭; 血管紧张素Ⅱ; 醛固酮; 心钠素
Keywords:
Hemofiltration; Refractory heart failure; Angiotensin Ⅱ; Aldosterone; Atrial natriuretic factor
分类号:
R446
摘要:
目的 探讨连续性血液净化(CBP)治疗顽固性心力衰竭(RHF)及对血浆血管紧张素Ⅱ(AngⅡ)、醛固酮(ALD)、心钠素(ANF)水平的影响。方法 应用CBP治疗35例RHF患者,检测治疗前后血压、心率、呼吸、血氧饱和度、血生化、血气分析、左心室射血分数(LVEF)及血浆AngⅡ、ALD、ANF等指标的变化和治疗效果。结果 应用CBP治疗后患者水肿明显减轻,收缩压、舒张压下降,心率、呼吸减慢,血氧饱和度升高,血清钾、钠、氯恢复正常,尿素氮及血肌酐下降;血pH值、血碳酸氢根升高,血氧分压升高,LVEF明显增加,心功能明显改善,血浆AngⅡ、ALD、ANF显著降低,统计学有明显差异。结论 CBP能有效纠正RHF患者水、电解质、酸碱平衡紊乱,降低血浆AngⅡ、ALD、ANF水平,纠正心力衰竭,短期效果佳。
Abstract:
Objective To investigate the application of continuous blood purification (CBP) and the effect of the angiotensin Ⅱ (Ang Ⅱ), aldosterone (ALD), atrial natriuretic peptide (ANP) in plasma with refractory heart failure(RHF) treated by CBP. Methods 35 eases with RHF were treated by CBP. Blood pressure, heart rate, respiration, blood oxygen saturation, blood markers of biochemistry, blood gas analysis, left ventricle ejection fraction (LVEF), cardiac function and AnglI, ALD, ANF in plasma were checked before and after treatment. Results The systolic pressure, diastolic pressure, heart rate, respiration, serum creatinine, blood urea nitroge, Ang Ⅱ, ALD, ANF in plasm after treatment were signifycanfly lower than those before treatment of CBP (P<0.05, P<0.01). The pH, HCO3-, PaO2, LVEF after treatment were significantly higher than those before treatment of CBP (P<0.05, P<0.01). The edema of the patients was relieved, and the K+, Na+, Cl- of blood serum were recovered normal after treatment, and cardiac function was recovered(P<0.05, P<0.01). Conclusion In the patients with RHF, CBP can efficiently treat the water-electrolyte disturbance, keep the acid-base balance, decrease the levels of AngⅡ, ALD, ANF in plasma, clear the inflammatory mediator and improve cardiac function.

参考文献/References:

1 戴闺柱.慢性收缩性心力衰竭治疗建议.中华心血管病杂志,2002,30(1):7-9.
2 Smith SC Jr,Dove JT,Jacobs AK,et al.ACC/AHA guidelines of percutaneous coronary interventions (revision of the 1993 PTCA guidelines) executive summary a report of the American college of Cardiology/American Heart Association Task Force on Practice Guidelines (committee to revise the 1993 guidelines for percutaneous transluminal coronary angioplasty).Circulation,2001,103(24):3019-3041.
3 Abraham WT.Rationale and design of a randomized clinical trial to assess the safety and efficacy of cardiac resynchronization therapy in patients with advanced heart failure:the Multicenter lnsync Randomized Clinical Evaluation (MIRACLE).Card Fail,2000,6(4):369-380.
4 Lau CP,Yu CM,Chsu E,et al.Reversal of left ventricular remodeling by synchronous biventricular pacing in heart failure.PACE,2000,23(11pt2):1722-1725.
5 Nelson GS,Berger RD,Fetics BJ,et al.Left ventricular or biventricular pacing improves cardiac function at diminished energy cost in patients with dilated cardiomyopathy and left bundle-brunch block.Circulation,2000,102(25):3053-3059.
6 Yu CM,Chau E,Sanderson JE.Tissue doppler echocardiographc evidence of reverse remodeling and improved synchronicity by simultaneously delaying regional contraction after biventricular pacing therapy in heart failure.Circulation,2002,105(4):438-445.

备注/Memo

备注/Memo:
收稿日期:2005-11-27。
通讯作者:蔡迅,E-mail:drcaixun@sohu.com
更新日期/Last Update: 1900-01-01