[1]龙贤辉,周平坤.缝隙连接蛋白43基因及其辐射诱导表达反应[J].国际放射医学核医学杂志,2005,29(6):269-271.
 LONG Xian-hui,ZHOU Ping-kun.Connexin43 gene and its irradiation-induced expression[J].International Journal of Radiation Medicine and Nuclear Medicine,2005,29(6):269-271.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
29
期数:
2005年第6期
页码:
269-271
栏目:
放射医学
出版日期:
1900-01-01

文章信息/Info

Title:
Connexin43 gene and its irradiation-induced expression
作者:
龙贤辉1 周平坤2
1. 421002 衡阳, 南华大学公共卫生学院卫生毒理学教研室;
2. 100850 北京, 军事医学科学院放射与辐射医学研究所
Author(s):
LONG Xian-hui1 ZHOU Ping-kun2
1. School of Public Health, Nanhua University, Henyang, Hunan Province 421001, China;
2. Department of Radiation Toxicology and Oncology, Beijing lnstitute of Radiation Medicine, Beijing 100850, China
关键词:
缝隙连接蛋白43细胞间通讯低剂量电离辐射基因表达
Keywords:
connexin43intercellular communicationlow dose ionizing radiationgene expression
分类号:
R979.1;Q691.9
摘要:
由缝隙连接蛋白构成的膜通道是相邻细胞间细胞通讯方式之一。缝隙连接蛋白是一超基因家族,其中缝隙连接蛋白43分布最为广泛,它在调控细胞增殖及分化、维持细胞内环境稳态、维护机体正常发育、血细胞形成等方面有着重要的生理功能。最新研究表明,低剂量电离辐射能诱导该基因高表达,由此,从分子水平揭示了细胞间通讯在低剂量辐射反应中的作用,而且缝隙连接蛋白43还有可能被发展成新的辐射损伤生物分子标记物。
Abstract:
Gap junctions, composed of connexin protein subunits, provide the important channel for the intercellular communication. Connexin43, the most popular component of the connexin protein family, is widely expressed in multiple tissues and cell lines and plays an important role in cell proliferation, differention and tissue homeostasis. Recently it was reported that the expression of connexin43 gene is remarkedly up-regulated by low dose ionizing radiation, the available data suggest connexin43 gene to be a poten-tial sensitive bio-marker in radiation damage.

参考文献/References:

1 Kumar NM, Gilula NB. The gap junction communication channel[J].Cell, 1996, 84(3):381-388.
2 Alexander DB, Goldberg GS. Transfer of biologically important molecules between cells through gap junction channels[J]. Curr Med Chem, 2003,10(19):2045-2058.
3 Willecke K, Eiberger J, Degen J, et al. Structural and functional diversity of connexin genes in the mouse and human genome[J].Biol chem, 2002, 383(5):725-737.
4 Cesen-Cummings K, Fernstyom M J, Malkinson AM, et al. Frequent reduction of gap junctional intercellular communication and Connexin43 expression in human and mouse lung carcinoma cells[J].Carcinogenesis, 1998, 19(1):61-67.
5 Huang RP, Fan Y, Hossain MZ, et al. Reversion of the neoplatic phenotype of human glioblastoma cells by connexin43[J]. Cancer Res,1998, 58(22):5089-5096.
6 Ruochun H, Ying L, Cheng C, et al. Connexin43 suppresses human glioblastoma cell growth by down-regulation of monocyte chemotactic protein 1, as discovered using protein array technology[J]. Cancer Res, 2002, 62(10):2806-2812.
7 Fernstrom M J, Koffler LD, Abou-Rjaily G, et al. Neoplastic reversal of human ovarian carcinoma cells transfected with connexin43[J].Exp Mol Pathol, 2002, 73(1):54-60.
8 King TJ, Fukushima LH, Donlon TA, et al. Correlation between growth control, neoplastic potential and endogenous connexin43 expression in Hela cell line:implications for tumor progression[J].Carcinogenesis, 2000, 21(2):311-315.
9 Chen JT, Cheng YW, Chou MC, et al. The correlation between aberrant connexin43 mRNA expressioninduced by promoter methylation and nodal micrometastasis in non-small cell lung cancer[J]. Clin Cancer Res, 2003, 9(11):4200-4204.
10 吴德昌,陈家佩,毛秉智.放射医学(M).北京:军事医学科学院出版社,2001.458-461.
11 Provost N, Moreau M, Leturque A, et al. Ultravieleta radiation transiently disrupts gap junctional communication in human keratinocytes[J]. Am J physiol Cell Physiol, 2003, 284(1):C51-C59.
12 Lecanda F, Warlow PM, Sheikh S, et al. Connexin43 deficiency causes delayed ossification, craniofacial abnormalities, and osteoblast dysfunction[J]. J Cell Biol, 2000, 151(4):931-944.
13 Monocino-Rodriguez E, Leathers H, Dorshkind K. Expression of connexin43(Cx43) is critical for normal hematopoiesis[J]. Blood,2000, 96(3):917-924.
14 Oviedo-Orta E, Hoy T, Evans WH. Intercelluar communication in the immune system:differential expression of connexin40 and 43,and perturbation of gap junction channel functions in peripheral blood and tonsil human lymphocyte subpopulations[J].Immunology,2000. 99(4):578-590.
15 Di WL, Lachelin GC, McGarrigle HH, et al. Oestriol and oestradiol increase cell to cell communication and connexin43 protein expression in human myometrium[J]. Mol Hum Reprod, 2001, 7(7):671-679.
16 Azzam El, de Toledo SM, Little JB. Expression of connexin43 is highly sensitive to ionizing radiation and other environmental stresses[J]. Cancer Res, 2003, 63(21):7128-7135.
17 Glover D, Little JB, Lavin MF, et al. Gueven low dose ionizing radiation induced activation of connexin43 expression[J]. Int J Radiat Biol, 2003, 79(12):955-964.
18 Yu W, Dahi G, Werner R. The connexin43 gene is responsive to oestrogen[J]. Proc Biol Sci, 1994, 255(1334):125-132.
19 Chen ZQ, Lefebvre D, Bai XH, et al. 1dentication of two regulatory elements within the promoter region of the mouse connexin 43 gene[J]. Biol Chem, 1995, 270(8):3863-3868.
20 Holder JW, Elmore E, Barrett JC. Gap junction function and cancer[J]. Cancer Res, 1993, 53(15):3475-3485.
21 Saez JC, Martinez AD, Branes MC, et al. Regulation of gap junctions by protein phosphorylation[J]. Braz J Med Biol Res, 1998, 31(5):593-600.
22 Rivedal E, Opsahl H. Role of PKC and MAP kinase in EGF and TPA-induces connexin43 phosphorylation and inhibition of gap junction intercellular communication in rat liver epithelial cells[J]. Carcinogenesis, 2001, 22(9):1543-1550.
23 Lampe PD, TenBroek EM, Burr JM, et al. Phosphorylation of connexin43 on serine 368 by protein kinase C regulates gap junctional communication[J]. Cell Biol, 2000, 149(7):1503-1512.

备注/Memo

备注/Memo:
收稿日期:2005-01-10。
更新日期/Last Update: 1900-01-01