[1]邹钢,邵豪,陆泽元,等.2型糖尿病胃轻瘫患者胰岛β细胞功能和胰岛素抵抗的评价及临床意义[J].国际放射医学核医学杂志,2005,29(6):261-264.
　ZOU Gang,SHAO Hao,LU Ze-yuan,et al.A study of the pancreatic islet β-cell function and insulin resistance of type2 diabetic gastroparesis[J].International Journal of Radiation Medicine and Nuclear Medicine,2005,29(6):261-264.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
29
期数:
2005年第6期
页码:
261-264
栏目:
论著
出版日期:
1900-01-01

文章信息/Info

Title:
A study of the pancreatic islet β-cell function and insulin resistance of type2 diabetic gastroparesis
作者:
邹钢1;  邵豪1;  陆泽元1;  丁玉珍1;  陈观榕2;  傅娟3
1.518033 深圳, 深圳市第四人民医院内分泌科;
2. 518033 深圳, 深圳市第四人民医院消化内科;
3. 518033 深圳, 深圳市第四人民医院超声
Author(s):
ZOU Gang1;  SHAO Hao1;  LU Ze-yuan1;  DING Yu-zhen1;  CHEN Guan-rong2;  FU Juan3
1. Department of Endoerinology, The Fourth People’s Hospital, Shenzhen 518033, China;
2. Department of Gastroenterology, The Fourth People’s Hospital, Shenzhen 518033, China;
3. Ultrasound Department, The Fourth People’s Hospital, Shenzhen 518033, China
关键词:
糖尿病胃轻瘫; β细胞功能; 胰岛素抵抗
Keywords:
diabetic gastroparesis; β-cell function; insulin resistance
分类号:
R587.1
摘要:
目的 探讨超重或肥胖的2型糖尿病胃轻瘫患者胰岛β细胞功能和胰岛素抵抗及临床意义。方法 用放免分析法分别测定正常对照(NGT)组31例、葡萄糖耐量受损(IGT)组32例、2型糖尿病(T2DM)组38例、糖尿病胃轻瘫(DGP)组31例空腹及食用馒头餐后30min、60min、120min、180min的血糖和胰岛素,考查胰岛素曲线下面积(INSAUC)、校正的β细胞功能指数(MBCI)及Homa胰岛素抵抗(Homa-IR)指数的变化。结果 IGT、T2DM、NGT、DGP的INSAUC值依次降低,四组两两比较,存在显著差异。NGT、IGT、T2DM、DGP的MBCI值依次降低,两两比较存在显著差异。NGT、IGT、DGP、T2DM的Homa-IR指数依次升高,除T2DM和DGP比较无统计学差异外,其余各组两两比较均存在显著差异。结论 糖尿病胃轻瘫患者胰岛β细胞功能较NGT、IGT和T2DM差,胰岛素抵抗较NGT和IGT强。
Abstract:
Objective To study the pancreatic islet β-cell function and insulin resistance of diabetic gastroparesis (DGP). Methods 31 subjects with normal glucose tolerance (NGT), 32 subjects with impaired glucose tolerance(IGT), 38 subjects with type 2 diabetes mellitus (T2DM) and 31 subjects with DGP were en-rolled in the study, assessed by steamed bread meal tests, the plasma glucose and insulin at 0, 30, 60, 120 and 180 min were respectively measured by using glucose oxidase and radioimmunoassay, investigate the changes of area under insulin cure (INSAUC), Homa-insulin resistance (Homa-IR) index and modified β-cell function index (MBCI). Results The INSAUC ofIGT, T2DM, NGT and DGP fell in turn, there were signif-icantly differences among the groups. The MBCI of NGT, IGT, T2DM and DGP fell in turn, there were significantly differences among the groups. The Homa-IR index of NGT, IGT, DGP and T2DM rose in turn, there were significantly differences among the groupsexcept between T2DM and DGP. Conclusions The pancreatic islet β-cell function of DGP was worse than NGT, IGT and T2DM, and the insulin resistance was stronger than NGT and IGT.

参考文献/References:

1 张绍刚,程留芳,白梅,等.2型糖尿病胃轻瘫患者胃肠激素水平的测定[J].中国综合临床,2002,18(5):433-434.
2 李光伟,杨文英,胡英华.以(FPG*FINS)/(PG60+PG120-2FPB)评估胰岛β细胞分泌功能的可能性探讨[J].中华内科杂志,2000,39(5):232-235.
3 Haffner SM, Gonzalez C, Miettinen H, et al. A prospective analusis of the HOMA model. The Mexico city diabetes study[J]. Diabetes Care, 1996, 19:1138-1141.
4 杨文英.胰岛素治疗临床实践中的经验和教训[J].国外医学内分泌学分册,2003,23(3):169-170.
5 李光伟.Bennett PH.糖尿病流行病学研究中应用OGTT资料评胰岛β细胞功能的可能性[J].中华内分泌代谢杂志,2003,19(1):8-12.

备注/Memo

备注/Memo:
收稿日期:2005-03-07。
更新日期/Last Update: 1900-01-01