[1]邹跃,周湘艳.端粒酶在肿瘤临床诊治中的应用前景[J].国际放射医学核医学杂志,2003,27(3):141-143.
　ZOU Yue,ZHOU Xiang-yan.The prospects of clinical application of telomerase in tumor diagnosis and tumor therapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2003,27(3):141-143.
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端粒酶在肿瘤临床诊治中的应用前景(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
27
期数:
2003年第3期
页码:
141-143
栏目:
综述
出版日期:
1900-01-01

文章信息/Info

Title:
The prospects of clinical application of telomerase in tumor diagnosis and tumor therapy
作者:
邹跃1;  周湘艳2
1. 100088 北京, 解放军第二炮兵总医院肿瘤科;
2. 100088 北京, 中国疾病预防控制中心辐射防护与核安全医学所
Author(s):
ZOU Yue1;  ZHOU Xiang-yan2
1. Department of oncology, The PLA Second Artillery General Hospital, Beijing 100088, China;
2. Institute for Radiological Protection and Nuclear Safety, Chinese Center for Disease Control and Prevention, Beijing 100088, China
关键词:
端粒酶; 肿瘤诊断; 肿瘤治疗
Keywords:
telomerase; tumor diagnosis; tumor therapy
分类号:
R730.4;R730.5
摘要:
端粒酶与肿瘤关系密切。近年来,相关的实验研究为临床应用端粒酶作为肿瘤诊断的标志物、端粒酶抑制剂作为抗肿瘤药物、以及端粒酶作为放疗中的重要影响因素提供了更加清晰的线索和有用的资料。
Abstract:
Telomerase is closely associated with tumors. Clearer clues and useful data obtained from recent experimental studies on telomerase make it possible that telomerase may be used as a marker of tumor diagnosis, telomerase inhibitors applied as antitumor drugs, and telomerase considered as an important factor in radiotherapy.

参考文献/References:

[1] Itoi T, Ohyashiki K, Yahata N, et al. Detection of telom-erase activity in exfloliated cancer cells obtained from bile[J]. Int J Oncol, 1999,15:1061-1067.
[2] Bryan TM, Cech TR. Telomerase maintenance of chromosome ends[J]. Curr Opin Biol, 1999,11:318-324.
[3] Hwang CF, Su CY, Kou SC, et al. Diagnostic usefulness of telomerase activity in nasopharyngeal carcinoma[J]. Jpn J Cancer Res, 2000, 91:706-766.
[4] Rha SY, Izbicka E, Lawrence R, et al. Effect of telomere and telomerase interactive agents on human tumor cell lines[J]. Clin Caner Res, 2000, 6:987-993.
[5] Feng J, Funk WD, Wang SS, et al. The RNA component human telomerase[J]. Science, 1995, 269:1236-1241.
[6] Karlseder J, Brocconi D, Dai Y, et al. P53- and ATM-dependent apoptosis induced by telomeres lacking TRF2[J]. Science, 1999,283:1321-1325.
[7] Kondo S, Tanaka Y, Kondo Y, et al. Antisense telomerase treatment, induction of two distinct pathway, apoptosis and differenciation[J]. FASEB J, 1998, 12:801-811.
[8] Finno P, Silver AR, Bouffler SD. Upregulation of telimerase activity by X-irradiation in mouse leukemia cells is independent of Tert,Terc,Tnks and Myc transcription[J]. Carcinogenesis, 2000, 21:573-578.
[9] Zhao P, Zhi JL, Yali L, et al. Expression telomerase reverse transcriptase in radiation-induced chronic human skin ulcer[J]. J Environ Pathol Toxicol Oncol, 2002, 21:67-70.
[10] Hande MP, Lansdorp MP and Natarajan AT. Induction of telomerase activity by in vivo X-irradiation of mouse splenocytes and its possible role in chromosome healing[J]. Mutat Res, 1998, 404:205-214.
[11] Lin Z, Lim S, Viani MA, et al. Down-regulation of telom-erase activity in malignant lymphomas by radiation and chemotherapeutic agents[J]. Am J Path, 2001, 159:711-719.

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　QIN Guang-ming.Current researches and prospective of radiolabeled antisense imaging in tumor[J].International Journal of Radiation Medicine and Nuclear Medicine,2001,25(3):213.
[2]朱涵能,熊思东,程文英.端粒酶相关蛋白研究新进展[J].国际放射医学核医学杂志,1998,22(2):77.
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[5]赵永良,吴德昌.端粒及端粒酶变化在肿瘤发生中的作用[J].国际放射医学核医学杂志,1997,21(5):222.

备注/Memo

备注/Memo:
收稿日期:2002-11-08。
作者简介:邹跃(1958-),男,博士研究生,副主任医师,主要从事肿瘤放疗研究。;周湘艳(1938-),女,博士研究生导师,研究员,主要从事放射毒理学研究。
更新日期/Last Update: 1900-01-01