[1]杨晓诚,胡怀湘,霍力.放射性标记氨基酸的肿瘤基础研究[J].国际放射医学核医学杂志,2003,27(1):25-27.
　YANG Xiao-cheng,HU Huai-xiang,HUO Li.Radiolabeled amino acids were applied to basic aspects in oncology[J].International Journal of Radiation Medicine and Nuclear Medicine,2003,27(1):25-27.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
27
期数:
2003年第1期
页码:
25-27
栏目:
核医学
出版日期:
1900-01-01

文章信息/Info

Title:
Radiolabeled amino acids were applied to basic aspects in oncology
作者:
杨晓诚1;  胡怀湘2;  霍力2
1. 245000 黄山市, 黄山市人民医院核医学科;
2. 100034 北京, 北京大学第一医院核医学科
Author(s):
YANG Xiao-cheng1;  HU Huai-xiang2;  HUO Li2
Department of Nuclear Medicine, People’s Hospital of Huangshan City, Huangshan 245000, China
关键词:
放射性标记氨基酸; 11C-蛋氨酸; 11C-酪氨酸; 123I-碘代甲基酪氨酸; 肿瘤显像
Keywords:
radiolabeled amino acids; 11C-methionine; 11C-tyrosine; 123I-iodomethyltyrosine; tumor imaging
分类号:
R817.4
摘要:
随着代谢显像的不断发展,放射性标记氨基酸引起临床更多关注。弄清氨基酸代谢基础和标记氨基酸在肿瘤中的作用更显必要。目前临床最常用的氨基酸显像剂如11C-蛋氨酸、11C-酪氨酸和123I-碘代甲基酪氨酸等,与18F-FDG PET相比很少受炎症影响,对脑部肿瘤显像准确性更好,对其他类型肿瘤也显示出更多的临床意义。
Abstract:
As the applications of metabolic imaging are expanding, radiolabeled amino acids has gained increased clinical interest. It is necessary to understand the basic aspects of amino acid metabolism and radiolabeled|and finally describe in the tumors. Have been most used clinically, such as, 11C-methionine, 11C-tyrosine and 123I-iodomethyltyrosine. And the theoretic and clinical back-ground of amino acid imaging is clear and is fit for clinical applications. Contrasting with the 18F-FDG PET suggested that is less troubled by interfering uptake in inflammatory tissues. There is a more accuracy in the brain tumors specially. In the other tumor types has been shown sufficiently.

参考文献/References:

[1] Saier MH, Daniels GA, Boemer P, et al. amino acid transport systems in animal cells:Potential targets of oncogene action and regulators of cellular growth[J]. J Membr Biol, 1988, 104:1-20.
[2] Souba WW, Pacitti AJ. How amino acids get into cells:machnisms, models, menusand mediators[J]. J Parenter Enteral Nutr, 1992, 16:569-578.
[3] Jager PL, Vaalburg W, Pruim J, et al. Radiolabeled amino acids:Basic aspects and clinical application in oncology[J]. J Nucl Med, 2001, 42:432-445.
[4] Langstrom B, Antoni G, Gullberg P, et al. Synthesis of Land D-[methyl-11C] methionine[J]. J Nucl Med, 1987, 28:1037-1040.
[5] Kubota K, Ishiwata K, Kubota R, et al. Tracer feasibility for monitoring tumor radiotherapy, a quadruple tracer study with flulrine-18-fluorodoexyglucose or fluorine-18-fluo-rodeoxyuridine, L-[methyl-11C-] methionine,[6-3H] thymidine,and gallium-67[J]. J Nucl Med,1991,32:2118-2123.
[6] Daemen BJG, Elsinga PH, Paans AMJ, et al. Radiation-induced inhibition of tumor growth as monitored by PET using L-[1-11C] tyrosine and fluorine-18-fluorodeoxyglucose[J]. J Nucl Med, 1992, 22:373-379.
[7] Langen KJ, Muhlensiepen H, Holschbach M, et al. Transport mechanisms of I-123 iodo-alphamethyl-L-Ltyro-sine in a human glioma cell line:comparison with [methyl-3H]-L-methionine[J]. J Nucl Med, 2000, 41:1250-1255.
[8] Jager PL, Franssen EJ, Kool W, et al. Feasibility of tumor imaging using L-3-[iodine-123] -iodo-alpha-methyl-tyrosine in extracranial tumors[J]. J Nucl Med, 1998, 39:1736-1743.
[9] Jager PL, Plaat BE, Vriesde EG, et al. Imaging of soft-tis-sue tumors using L-3-[iodine-123] iodo-alpha-methyl-tyro-sine SPECT:comparison with proliferative and mitotic activity, cellularity and vascularity[J]. Clin Cancer Res, 2000, 6:2252-2259.

相似文献/References:

[1]华逢春.11C-METPET在脑肿瘤中的应用[J].国际放射医学核医学杂志,2002,26(1):1.
　HUA Feng-chun.The applications of 11C-MET PET in brain tumor[J].International Journal of Radiation Medicine and Nuclear Medicine,2002,26(1):1.
[2]陈立波.用于肿瘤代谢显像的几种放射性标记氨基酸[J].国际放射医学核医学杂志,2002,26(1):18.
　CHEN Li-bo.The clinical application of radiolabeled amino acids in tumor imaging[J].International Journal of Radiation Medicine and Nuclear Medicine,2002,26(1):18.

备注/Memo

备注/Memo:
收稿日期:2002-10-20。
作者简介:杨晓诚(1955-),男,主治医师,主要从事临床核医学研究。;胡怀湘(1967-),女,硕士研究生,主要从事临床核医学研究。;霍力(1969-),女,主治医师,主要从事临床核医学研究。
更新日期/Last Update: 1900-01-01