[1]王丹.硼中子俘获治疗的辐射场特点与剂量估算[J].国际放射医学核医学杂志,2002,26(2):87-89.
　WANG Dan.Characteristics of radiation field and dosimetry of born neutron capture therapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2002,26(2):87-89.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
26
期数:
2002年第2期
页码:
87-89
栏目:
综述
出版日期:
1900-01-01

文章信息/Info

Title:
Characteristics of radiation field and dosimetry of born neutron capture therapy
作者:
王丹
300192 天津, 中国医学科学院中国协和医科大学放射医学研究所
Author(s):
WANG Dan
Institution of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China
关键词:
硼中子俘获治疗; 中子束; 剂量测定
Keywords:
boron neutron capture therapy; neutron beam; dosimetry
分类号:
T144.1;R730.55
摘要:
BNCT(硼中子俘获治疗)基于这样一种思想:10B的载体化合物会优先选择癌细胞作为靶而后与热中子反应,进而产生高能、短射程裂变产物α粒子和Li粒子。它是一种双重的靶向治疗方法。BNCT的治疗效果依赖于两个主要因素:源于10B(n,α)7Li核反应的高LET(传能线密度)粒子的生物效应和在靶细胞及其特异区域内的硼沉积。本文总结和探讨了BNCT的发展概况、辐射场的特点以及吸收剂量的计算方法。
Abstract:
Boron neutron capture therapy (BNCT) is based on the nuclear reaction that occurs when boron-10 is irradiated with low-energy thermal neutrons to yield alpha particles and recoiling lithium-7 nuclei which have high energy and shortrange. BNCT is a binary approach:a boron-labeled compound is administered that delivered high concentration of 10B of the target tumor relative to the surrounding tissues. The therapeutic efficiency of BNCT is depended upon RBE and LET of the reaction and particles and the boron selectivity to cancerous cells. The development of BNCT, characteristic of radiation fields and calculations of energy deposition are described in this paper.

参考文献/References:

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[2] Morris GM,Smith DR,Patel H, et al. Boron microlocalization in oral mucosal tissue:implications for boron neutron capture therapy[J].Br J Cancer,2000,82(11):1764-1771.
[3] Barth RF,Yang W,Rotaru JH, et al. Boron neutron capture therapy of brain tumors:enhanced survival and cure following blood-brain barrier disruption and intracarotid injection of sodium borocaptate and boron ophenylalanine[J].Int J Radiat Oncol Biol Phys,2000,47(1):209-218.
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[5] Allen DA,Beynon TD. What is the best proton energy for accelerator-based BNCT using the 7Li(p,n)7Be reaction?[J].Med Phy,2000,27(5):1113-1118.
[6] Biscegliet E,Colangelo P,Colonna N, et al. On the optimal energy of epithermal neutron beams for BNCT[J].Phys Med Biol,2000,45(1):49-58.
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[8] Jeffre A,Michael S,Makar, et al. Derivations of relative biological effectiveness for the high-let radiations produced during boron neutron capture irradiations of the 9L rat gliosarcoma in vitro and in vivo[J].Int J Radiat Oncol Biol Phys,1993,27:1121-1129.
[9] Lee CL,Zhou XL,Kudchadker R J, et al. A Monte Carlo dosimetry-based evaluation of the 7Li(p,n)7Be reaction near threshold for accelerator boron neutron capture therapy[J].Med Phys,2000,27(1):192-202.
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[11] Pavanetto F,Perugini P,Genta I, et al. Boron-loaded liposomes in the treatment of hepatic metastases:preliminary investigation by auto-radiography analysis[J].Drug Deliv,2000,7(2):97-103.
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相似文献/References:

[1]张晓敏,张文仲,骆亿生.硼中子俘获治疗技术的研究现状[J].国际放射医学核医学杂志,2004,28(4):188.
　ZHANG Xiao-min,ZHANG Wen-zhong,LUO Yi-sheng.The research status of BNCT technique[J].International Journal of Radiation Medicine and Nuclear Medicine,2004,28(2):188.

备注/Memo

备注/Memo:
收稿日期:2001-11-15。
作者简介:王丹(1977-),女,黑龙江呼兰人,硕士研究生,主要从事外照射器官吸收剂量的研究。
更新日期/Last Update: 1900-01-01