[1]陈立波.用于肿瘤代谢显像的几种放射性标记氨基酸[J].国际放射医学核医学杂志,2002,26(1):18-20.
　CHEN Li-bo.The clinical application of radiolabeled amino acids in tumor imaging[J].International Journal of Radiation Medicine and Nuclear Medicine,2002,26(1):18-20.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
26
期数:
2002年第1期
页码:
18-20
栏目:
综述
出版日期:
1900-01-01

文章信息/Info

Title:
The clinical application of radiolabeled amino acids in tumor imaging
作者:
陈立波
200233 上海, 上海第六人民医院核医学科
Author(s):
CHEN Li-bo
Department of Nuclear Medicine, Shanghai Sixth People’s Hospital, Shanghai 200233, China
关键词:
放射性标记氨基酸; 11C-蛋氨酸; 11C-酪氨酸; 123I-甲基酪氨酸; 肿瘤显像
Keywords:
radiolabeled amino acids; 11C-methionine; 11C-tyrosine; 123I-iodomethytyrosine; tumor imaging
分类号:
R817.4
摘要:
随着代谢显像的广泛应用,放射性标记氨基酸越来越引起临床关注。与18F-FDGPET显像相比,氨基酸显像的优点在于其受炎症的影响较小。对于脑肿瘤,氨基酸代谢显像具有较高的诊断价值。对大多数其它类型的肿瘤而言,尽管凭现有资料尚不能得出最终结论,但其总体可行性已得到充分显示。因此,仍有必要进行经过精心设计的更大样本病例的研究。本文着重描述了11C-蛋氨酸(MET)、11C-酪氨酸(TYR)、123I-甲基酪氨酸(IMT)的基本特性和临床应用。
Abstract:
As the application of metabolic imaging are expanding, radio labeled amino acids may gain increased clinical interest.The fact that amino acid imaging is less influenced by inflammation may be advantageous in comparison with 18F-FDG PET imaging.In brain tumor, the diagnostic value of amino acid imaging is adequate.In most of other tumors, the data do not yet permit definitive conclusions, but the general feasibility of amino acid imaging has sufficiently been shown.More research is required in larger patient series and in well-defined clinical setting.This review mainly describes the basic aspects and clinical applications of 11C-methionine, 11C-tyrosine, and 123I-iodomethytyrosine.

参考文献/References:

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相似文献/References:

[1]华逢春.11C-METPET在脑肿瘤中的应用[J].国际放射医学核医学杂志,2002,26(1):1.
　HUA Feng-chun.The applications of 11C-MET PET in brain tumor[J].International Journal of Radiation Medicine and Nuclear Medicine,2002,26(1):1.
[2]杨晓诚,胡怀湘,霍力.放射性标记氨基酸的肿瘤基础研究[J].国际放射医学核医学杂志,2003,27(1):25.
　YANG Xiao-cheng,HU Huai-xiang,HUO Li.Radiolabeled amino acids were applied to basic aspects in oncology[J].International Journal of Radiation Medicine and Nuclear Medicine,2003,27(1):25.

备注/Memo

备注/Memo:
收稿日期:2002-2-6。
作者简介:陈立波(1973-),男,江苏盐城人,住院医师,苏州大学临床核医学硕士研究生,主要研究方向:分子核医学。
更新日期/Last Update: 1900-01-01