[1]郭万华.统计参数图在PET和SPECT脑功能显像中的应用[J].国际放射医学核医学杂志,2002,26(1):7-11.
　GUO Wan-hua.Application of statistical parametric mapping in PET and SPECT brain functional imaging[J].International Journal of Radiation Medicine and Nuclear Medicine,2002,26(1):7-11.
点击复制

统计参数图在PET和SPECT脑功能显像中的应用(/HTML)
分享到：

《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
26
期数:
2002年第1期
页码:
7-11
栏目:
综述
出版日期:
1900-01-01

文章信息/Info

Title:
Application of statistical parametric mapping in PET and SPECT brain functional imaging
作者:
郭万华
200025 上海, 上海第二医科大学
Author(s):
GUO Wan-hua
Department of Nuclear Medicine, Ruijing Hospital, SSMU, Shanghai 200025, China
关键词:
脑显像; 正电子发射断层显像; 单光子发射断层显像; 统计参数图
Keywords:
positron emission tomography; single photon emission computerized tomography; brain imaging; statistical parametric mapping
分类号:
R817.4
摘要:
感兴趣区(ROI)法是脑功能显像资料常用的分析方法,但由于其主观性强、重复性差等缺点使脑功能研究的精确性及效率显著降低,统计参数图(SPM)法是为解决这一问题而开发的以像素为基础的自动分析软件,该法将多种数理模型应用到针对全脑的像素统计推断中。本文介绍了该法的简单原理、主要应用模块组成和实际应用。该方法对认知领域、神经生物学和神经药理学的研究将起到一定的推动作用,必将随着脑科学进展的需要得到更广泛的应用。
Abstract:
Regional of interest (ROI) is the method regularly used to analyze brain functional imaging.But, due to its obvious shortcomings such as subjectivity and poor reproducibility, precise analyzing the brain function was seriously limited.Therefore, statistical parametric mapping (SPM) as an automatic analyze software was developed based on voxel or pixel to resolve this problem.Using numerous mathmatical models, it can be used to statistically assess the whole brain pixel.Present review introduces its main principle, modular composition and practical application.It can be concluded, with development of neuroscience, the SPM software will be used more widely in relative field, like neurobiology, cognition and neuropharmacology.

参考文献/References:

[1] Fox PT. Physiological ROI definition by image subtraction[J].J Cereb Blood Flow Metab, 1991,11:A79-A82.
[2] Friston KJ, Frith CD, Liddle PF, et al. Plastic Transformation of PET images[J]. J Comput Assist Tomogr, 1991, 15:634-639.
[3] Lin KP, Huang SC, Yu DC, et al. Automated image registration for FDOPA PET studies[J]. Phys Med Biol, 1996, 19:615-623.
[4] Minoshima S, Frey KA, Foster NL, et al. Preserved pontine glucose metabolism in Alzheimer disease:a reference region for functional brain image (PET) analysis[J]. J Comput Assiist Tomogr, 1995, 19:541-547.
[5] Syed GM, Eagger S, Toone BK, et al. Quantification of regionalcerebral blood flow(rCBF) using 99Tcm-HMPAO and SPECT:chose of the reference region[J]. J Nucl Med Commun,1992, 13:811-816.
[6] Dickson JC, Staff RT, Gemmell HG, et al. An assessment of perfusion deficits in decompression illness using 99Tcm HMPAO SPET and statistical parametric mapping[J]. Nucl Med Commun, 2001, 22(4):423-428.
[7] Migneco O, Benoit M, Koulibaly PM, et al. Perfusion brain SPECT and statistical parametric mapping analysis indicate that apathy is a cingulate syndrome:a study in Alzheimer’s disease and nondemented patients[J]. Neuroimage, 2001, 13(5):896-902.
[8] Martin AJ, Friston KJ, Colebatch JG, et al. Decreases in regional cerebral blood flow with normal aging[J]. J Cereb Blood Flow Metab, 1991, 11(4):684-689.
[9] Houle S, Kapur S, Rose R, et al. Absence of residual effects after physiological stimulation of the visual and motor cortex:an[15O]-H2O PET study in humans[J]. Nucl Med Commun, 1994,15(11):860-864.
[10] Maquet P, Peters J, Aerts J, et al. Functional neuroanatomy of human rapid-eye-movement sleep and dreaming[J]. Nature. 1996, 383(6596):163-166.
[11] Hugdahl K, Berardi A, Thompson WL, et al. Brain mechanisms in human classical conditioning:a PET blood flow study[J]. Neuroreport, 1995, 6(13):1723-1728.
[12] Holcomb HH, Gordon B, Loats HL et al.Brain metabolim patterns are sensitive to attentional effort associated with a tone recognition task[J]. Biol Psychiatry, 1996, 39(12):1013-1022.
[13] Ketter TA, Andreason PJ, George MS, et al. Anterior paralimbic mediation of procaine-induced emotional and psychosensory experiences[J]. Arch Gen Psychiatry, 1996, 53(1):59-69.
[14] Ragland JD, Gur RC, Lazarev MG, et al, Hemispheric activation of anterior and inferior prefrontal cortex during verbal encoding and recognition:a PET study of healthy volunteers[J]. Neuroimage, 2000, 11(6 Pt 1):624-633.
[15] Finelli LA, Landolt HP, Buck A, et al. Functional neuroanatomy of human sleep states after zolpidem and place bo:a H2 15O PET study[J]. J Sleep Res,2000, 9(2):161-173.
[16] Laureys S, Goldman S, Phillips C, et al.Fluorodopa uptake and glucose metabolism in early stages of corticobasal degeneration[J]. J Neural, 1999, 246(12):1151-1158.
[17] Verhoeff NP.[123I] Iomazenil SPECT benzodiazepine receptor imaging in schizophrenia[J]. Psychiatry Res, 1999, 91(3):163-173.
[18] Pawlik G, Thiel A. Transformation to normality and independence for parametric significance testing of data from multiple dependent volumes of interest[A]. Myers R et al. Quantification of brain function using PET[C], San Diego, Academic Press, 1996,349-352.
[19] Davatzikos C, Li HH, Herskovits E, et al. Accuracy and sensitivity of detection of activation foci in the brain via statistical parametric mapping:a study using a PET simulator[J]. Neuroimage, 2001, 13(1):176-184.

相似文献/References:

[1]周惠君,董萍,沈国华,等.11C-蛋氨酸PET/CT显像在脑胶质瘤中的应用价值[J].国际放射医学核医学杂志,2015,39(2):161.[doi:10.3760/cma.j.issn.1673-4114.2015.02.013]
　Zhou Huijun,Dong Ping,Shen Guohua,et al.Value of 11C-methionine PET/CT imaging indiagnosing cerebral glioma[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(1):161.[doi:10.3760/cma.j.issn.1673-4114.2015.02.013]
[2]李亚军,白人驹,高硕,等.兔VX2肺肿瘤PET-CT与血管生成的相关性研究[J].国际放射医学核医学杂志,2010,34(3):139.
　LI Ya-jun,BAI Ren-ju,GAO Shuo,et al.The correlation between PET-CT imaging and microvessed density in rabbit lung VX2 tumor model[J].International Journal of Radiation Medicine and Nuclear Medicine,2010,34(1):139.
[3]华逢春.11C-METPET在脑肿瘤中的应用[J].国际放射医学核医学杂志,2002,26(1):1.
　HUA Feng-chun.The applications of 11C-MET PET in brain tumor[J].International Journal of Radiation Medicine and Nuclear Medicine,2002,26(1):1.
[4]刘平安.PET在头颈部肿瘤的应用[J].国际放射医学核医学杂志,2002,26(1):12.
　LIU Ping-an.The applications of PET in head and neck oncology[J].International Journal of Radiation Medicine and Nuclear Medicine,2002,26(1):12.
[5]王淑侠,裴著果.延迟相心肌缺血预适应机制的核医学方法研究[J].国际放射医学核医学杂志,2001,25(1):1.
　WANG Shu-xia.Nuclear medicine methods in the field of studying the mechanisms of delayed phase of myocardial preconditioning[J].International Journal of Radiation Medicine and Nuclear Medicine,2001,25(1):1.
[6]管一晖.PET在垂体瘤诊断中的应用[J].国际放射医学核医学杂志,2001,25(1):7.
[7]张立颖.18F-FDG PET显像在恶性淋巴瘤中的应用[J].国际放射医学核医学杂志,2001,25(1):10.
　ZHANG Li-ying.The applications of 18F-FDG PET in malignant lymphoma[J].International Journal of Radiation Medicine and Nuclear Medicine,2001,25(1):10.
[8]涂彧.成人脑显像时组织吸收剂量及对患者的防护措施[J].国际放射医学核医学杂志,2001,25(3):115.
　TU Yu.The absorb doses and the safeguard for grown-up brain imaging[J].International Journal of Radiation Medicine and Nuclear Medicine,2001,25(1):115.
[9]史文琴.PET显像在卵巢癌诊断中的作用[J].国际放射医学核医学杂志,2001,25(4):158.
　SHI Wen-qin.The application of 18F-FDG PET in diagnosing of ovarian carcinoma[J].International Journal of Radiation Medicine and Nuclear Medicine,2001,25(1):158.
[10]王瑞民.阿尔茨海默病等痴呆疾病的脑功能影像学研究[J].国际放射医学核医学杂志,2001,25(5):209.
　WANG Rui-min.Functional neuroimaging of Alzheimer’s disease and other dementias[J].International Journal of Radiation Medicine and Nuclear Medicine,2001,25(1):209.

备注/Memo

备注/Memo:
收稿日期:2001-4-17。
作者简介:郭万华(1968-),男,安徽巢湖市人,影像医学与核医学博士研究生。
更新日期/Last Update: 1900-01-01