[1]刘杰.纤溶酶原激活剂及其活性测定[J].国际放射医学核医学杂志,2001,25(6):261-264.
 LIU Jie.Plasminogen activator and its assay of the activity[J].International Journal of Radiation Medicine and Nuclear Medicine,2001,25(6):261-264.
点击复制

纤溶酶原激活剂及其活性测定(/HTML)
分享到:

《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
25
期数:
2001年第6期
页码:
261-264
栏目:
综述
出版日期:
1900-01-01

文章信息/Info

Title:
Plasminogen activator and its assay of the activity
作者:
刘杰
300192 天津, 中国医学科学院中国协和医科大学放射医学研究所
Author(s):
LIU Jie
Peking Union Medical College, Institute of Radiation Medicine, Chinese Academy of Medical College, Tianjin 300192, China
关键词:
纤溶酶原激活剂纤溶酶血栓
Keywords:
plasminogen activatorplasminthrombi
分类号:
R556
摘要:
纤溶酶原激活剂(plasminogen activator,PA)是一种特异性的蛋白水解酶,它能将无活性的酶前体转变为纤溶酶(plasmin)。纤溶酶是一种有效的非特异性的蛋白水解酶,能够裂解血液内的纤维蛋白凝块使其成为可溶性的多肽。本文描述了纤港酶原激活系统的一些生化特征,及对纤溶酶原激活剂活性的测定方法。纤溶酶原激活剂在血栓性疾病和出血性疾病的诊断具有潜在应用价值。
Abstract:
Plasminogen activators (PA) are specific proteolytic enzymes Which convert the inactive proenzymen to plasmin.The plasmin formed is a potent and nonpecific protease which cleaves blood fabrin clots into soluble polypeplide. This article describes some biochemical chatacteristic of the different compotents of the plsminogen activator system,current methods for assay of the activity of the PA.The potential application of PA as diagnostic tools in diseases of the thrombi.

参考文献/References:

[1] Chiu WC, Gann DS, Darlington DN.Measuring plasminogen activator inhibitor activity in plasma by two enzymatic assays[J].J Biochem Biophys Methods, 2000, 45(2):127-140.
[2] van Baal WM, Emeis JJ, van der Mooren M J, et al.Impaired procoagulant-anticoagulant balance during hormone replacement therapy? A randomised, placebocontrolled 12-week study[J].Thromb Haemost, 2000, 83(1):29-34.
[3] Ince B, Bayram C, Harmanci H, et al.Hemostatic markers in ischemic stroke of undetermined etiology[J].Thromb Res, 1999, 96(3):169-174.
[4] Hong JJ.Hereditary defects in fibrinolysis associated with thrombosis[J].Semin Thromb Hemost, 1999, 25(3):321-331.
[5] Prisco D, Conti AA, Giurlani L.Clinical application of fibrinolysis laboratory tests:a review[J].Ann Ital Med Iht, 1998, 13(2):81-87.
[6] Ferrier CM, Sucin S, van Geloof WL, et al.Hight PA-expression in primary melanoma of the limb correlates with good prognosis[J].Br J Cancer, 2000, 83(10):1351-1359.
[7] Angles-Cano E.Structural basis for the pathophysiology of lipoprotein(a) in the athero-thrombotic process[J].Braz J Med Biol Res, 1997, 30(11):1271-1280.
[8] Mustonen P, Lepantalo M, Lassila R.Physical exertion induces thrombinformation and fibrin degradation in patients with peripheral atherosclerosis[J].Arterioscler Thromb Vasc Biol, 1998, 18(2):244-249.
[9] Chang LC, Meyerhoff ME, Yang VC.Electrochemical assay of plasminogen activators in plasma using polyion-sensitive membrane electro detection[J].Anal Biochem, 1999, 276(1):8-12.
[10] Gunther A, Markart P.Kalinowski M, et al.Cleavage of surfactant-incorporating fibrin by different fibrinolytic agents.Kinetics of lysis and rescue of surface acivity[J].Am J Respir Cell Mol Biol, 1999, 21(6):738-745.
[11] Michels HR, Hoffman JJ, Bar FW.Pharmacokinetics and hemostatic effects of saruplase in patients with acute myocardial infaretion:comparison of infusion, single-bolus, and split-bolus administration[J].J Thromb Thrombolysis, 1999, 8(3):213-221.
[12] Edelberg JM, Pizzo SV.Lipoprotein(a) in the regulation of fibrinolysis[J].J Atheroscler Thromb, 1995, 2:S5-S7.
[13] Mitropoulos KA.Lipid-thrombosis interfoce[J].Br Med Bull, 1994, 50(4):813-832.
[14] Redlitz A, Plow EF.Receptors for plasminogen and t-PA:an update[J].Baillieres Clin Haematol, 1995, 8(2):313-327.
[15] Bell WR.The fibrinolytic system in neoplasia[J].Semin Thromb Hemost, 1996, 22(6):459-478.
[16] Ikeda U, Yamamoto K, Shimada K.Biochemical markers of coagulation activation in mitral stenosis, atrial fibrillation, and cardiomyopathy[J].Clin Cardiol, 1997, 20(1):7-10.
[17] Feinberg WM, Macy E, Cornell ES, et al.Plasminalpha2-antiplasmin complex in patients with atrial fibrillation.Stroke prevention in atrial fibrillation investigators[J].Thromb Haemost, 1999, 82(1):100-103.

备注/Memo

备注/Memo:
收稿日期:2001-6-18。
作者简介:刘杰(1978-),女,山东海阳人,中国医学科学院、中国协和医科大学放射医学研究所硕士研究生,主要从事纤溶酶原激活剂活性测定研究。
更新日期/Last Update: 1900-01-01