[1]秦光明.肿瘤核素反义显像技术的研究现状与展望[J].国际放射医学核医学杂志,2001,25(5):213-216.
　QIN Guang-ming.Current researches and prospective of radiolabeled antisense imaging in tumor[J].International Journal of Radiation Medicine and Nuclear Medicine,2001,25(5):213-216.
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肿瘤核素反义显像技术的研究现状与展望(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
25
期数:
2001年第5期
页码:
213-216
栏目:
综述
出版日期:
1900-01-01

文章信息/Info

Title:
Current researches and prospective of radiolabeled antisense imaging in tumor
作者:
秦光明
430022 湖北 武汉, 华中科技大学同济医学院协和医院核医学科
Author(s):
QIN Guang-ming
Department of Nuclear Medicine, Union Hospital Tongji Medical University, Wuhan Hubei 430022, China
关键词:
反义显像; 肿瘤诊断; 寡聚核苷酸; 癌基因; 放射性核素
Keywords:
antisense imaging; tumor diagnose; oligonucleotide; oncogene; radionuclides
分类号:
R817.4
摘要:
反义显像具有不引起免疫反应、探针分子小、易进入瘤组织等优点,具有广阔的应用前景,但靶序列的选择、理想寡核苷酸的确定等仍是现阶段制约其发展的重要因素。因此,将反义显像引入体内研究还有很多问题需要解决,包括如何提高探针的体内稳定性、增加靶细胞的选择性摄取和滞留、降低血清蛋白非特异性结合等。
Abstract:
Radiolabeled antisense imaging may be defined as the detection of diseases through the administration of radiolabeled antisense oligonucleotide designed to bind in a sequence-specific manner to the machinery of translation or transcription. No immunogenity, low molecular weight of probes and easily penetrating the tumor cells are some of it’s good aspects.Despite its good prospective, factors as selection of targeted serial, identification of ideal oligonucleotides are still roadblocks in developing antisense imaging. Many problems must be solved before in vivo application of antisense imaging, among those including in vivo stability, specific absorption and retention by targeted cells, nonspecific serum binding, and so on.

参考文献/References:

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[10] Lu xiao-ming, Fischman AJ, Jyawook SL, et al. Antisense DNA delivery in vivo:liver targeting by receptor-mediated uptake[J]. J Nucl Med, 1994, 35:269-275.
[11] Dadon J, Blum HE. Receptor-mediated delivery of hepatitis B virus DNA and antisense oligodeoxynucleotides to avian liver cells[J]. Hepatology, 1996, 24:474-481.
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[13] David DFM, Wei Ai-qun. Enhanced delivery of synthetic oligonucleotides to human leukaemic cells by liposomes and immunoliposomes[J]. Leuk Res, 1996, 20:925-930.
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备注/Memo

备注/Memo:
收稿日期:2000/8/21。
基金项目:湖北省科委课题基金
作者简介:秦光明(1972-),男,湖北鄂州人,华中科技大学附属协和医院核医学科医师,硕士,主要研究肿瘤反义显像。
更新日期/Last Update: 1900-01-01