[1]川玲,赵文锐.99Tcm-MIBI在检测乳腺癌中的作用[J].国际放射医学核医学杂志,2000,24(4):155-157.
　CHUAN Ling,ZHAO Wen-rui.The role of 99Tcm-sestamibi in breast cancer diagnosis[J].International Journal of Radiation Medicine and Nuclear Medicine,2000,24(4):155-157.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
24
期数:
2000年第4期
页码:
155-157
栏目:
综述
出版日期:
1900-01-01

文章信息/Info

Title:
The role of 99Tcm-sestamibi in breast cancer diagnosis
作者:
川玲;  赵文锐
100037 北京, 海军总医院核医学科
Author(s):
CHUAN Ling;  ZHAO Wen-rui
Department of Nuclear Medicine, Navy General Hospital, Beijing 100037, China
关键词:
99Tcm-甲氧基异丁基异晴; 核素乳腺显像; 乳腺癌; 腋窝淋巴结
Keywords:
99Tcm-sestamibi; scintimammography; breast cancer; axillary lymph node
分类号:
R817.4
摘要:
99Tcm-MIBI(99Tcm-甲氧基异丁基异腈)是第一个经FDA(美国食品和药物管理局)批准作为乳腺显像剂的放射性药物。一些前瞻性研究已经显示,99Tcm-MIBI检测乳腺癌的敏感性为85%,特异性89%,阳性和阴性预测率分别是89%和84%。核素检测乳腺癌有其特殊的临床意义,特别是用于那些不能诊断和诊断有困难的乳腺疾病,评价高危人群,评价对放化疗的反应和检测腋窝转移淋巴结。
Abstract:
99Tcm-sestamibi was the first radiopharmaceutical to be approved by the FDA (Food and Drug Administration) for scintimammography. Some prospective studies have shown that the overall sensitivity of 99Tcm sestamibi scintimammography in detection of breast cancer was 85%, the specificity was 89%, and the positive and negative predictive values were 89% and 84% respectively. Scintimammography plays a special role in various clinical indications such as nondiagnostic or diffcult mammography and evaluation of high-risk patients, tumor response to chemotherapy, and axillary lymph node metastatic involvement.

参考文献/References:

[1] Aktolun C, Bayhan H, Kir M. Clnical experience widl Tc-99m M IBI imaging in patients with malignant tumomurs:preliminary results and comparison with Tl-201[J]. Clin Nucl Med, 1992, 17:171-176.
[2] Crane PD, Onthank DC, Bourque CR, et al. Autoradiography and radioscintigraphy of technetium-99m-sestamibi in c-neu transgenic mice[J]. J Nucl Med, 1995, 36:1862-1868.
[3] Scopinaro F, Schillaci O, Scarpini M, et al. Technetium-99m sestamibi an indicator of breast cancer invasiveness[J]. Eur J Nucl Med, 1994, 21:984-987.
[4] Khalkhali I, Mena I, Jouanne E, et al. Prone scinti-mammography in patients with suspicion of carcinoma of the breast[J]. J Am Coll Surg, 1994, 178:491-497.
[5] Lu G, Shih W J, Huang HY, et al. 99mTc-MIBI mammoscintigraphy ot breast masses:early and delayed imaging[J]. Nucl Med Commun, 1995, 16:150156.
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[8] Taillefer R. The role of 99mTc-sestamibi and other conventional radiopharmaceuticals in breast cancer diagnosis[J]. Semin Nucl Med, 1999, 29:22-23.
[9] Alazraki NP, Eshima D, Eshima LA, et al. Lymphoscintigraphy, the sentinel node concept and the intraoperative gamma probe in melanoma, breast cancer, and other potential cancers[J]. Semin Nucl Med, 1997, 27:55-67.
[10] Maublant J, de Latour M, Mestas D, et al. Technetium-99m-sestamibi uptake in breast tumor and associated lymph nodes[J]. J Nucl Med, 1996, 37:922-925.
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备注/Memo

备注/Memo:
收稿日期:1999-11-23。
作者简介:川玲(1951-),女,四川通江人,海军总医院核医学科副主任医师,硕士,主要从事心脏核医学研究。;赵文锐(1963-)男,山西昔阳人,海军总医院核医学科主治医师,硕士,主要研究方向:泌尿系统显像。
更新日期/Last Update: 1900-01-01