[1]徐志勇.放射免疫治疗计划研究[J].国际放射医学核医学杂志,2000,24(3):100-103.
　XU Zhi-yong.Study of Treatment planning for radio-immunotherapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2000,24(3):100-103.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
24
期数:
2000年第3期
页码:
100-103
栏目:
综述
出版日期:
1900-01-01

文章信息/Info

Title:
Study of Treatment planning for radio-immunotherapy
作者:
徐志勇
300192 天津, 中国医学科学院中国协和医科大学放射医学研究所物理剂量室
Author(s):
XU Zhi-yong
Institute of radiation Medical, Chinese Academy of Medical sciences and Peking union medical college, Tianjin 300192, China
关键词:
放射免疫治疗计划; 图像融合; 剂量点核; Monte Carlo输运
Keywords:
treatment for radio-immunothepary; image fusion; dose-point kernel Monte; Carlo transport
分类号:
R144. 1
摘要:
放射免疫治疗(RIT)计划是通过收集治疗前病人的特定信息如活度分布等来指导具体治疗,它的目的是使病人的肿瘤灶得到治疗剂量的同时周围的重要器官在耐受量以内。要得到好的RIT疗效,必须知道以下三点:带有放射性核素的载体在病人体内的空间分布和定量;在这种分布下肿瘤灶和重要器官的吸收剂量;用CT或MRI、以及CT或MRI与其它放射影像结合来获得肿瘤和重要器官的体积。本文总结和探讨了目前使用的各种放射免疫治疗计划及这些治疗计划中使用的活度定量方法、体积确定方法和吸收剂量计算方法。
Abstract:
RIT treatment planning is improve therapy by collecting patient-specific information (such as the activity distribution) before treatment. Its objective maximizes the dose absorbed by the tumor while minimizing the toxicity to normal tissue. To gain good healing effect in RIT, one needs to determine:the quantity and spatial distribution of the administered radionuclide carrier in the patient over time; the absorbed dose in the tumor sites and critical organs based on this distribution; the volume of tumor and critical organs from CT or MRI and appropriately correlated with nuclear medicine imaging techniques. This article conclude and discuse various RIT treatment planning used present and quantitation of activity, volume determination and calculation of absorbed dose that are used in these treatment planning.

参考文献/References:

[1] Edit AK, Erdit Y, Yorke ED, et al. Treatment planning for radio-immunotherapy[J]. Phys Med Biol, 1996, 41:2009~2026.
[2] Wang L, Chul CS, Lovelock M. A patient-specific Monte Carlo dose-calculation method for photon beams[J]. Med Phys, 1998, 25(6):867~878.
[3] Magnus T. A Monte carlo program converting activity distributions to absorbed dose distributions in a radionuclide treatment planning systsm[J]. Acta Oncological, 1996, 35(3):367~372.
[4] Parsai EI,Ayyangar KM, Dobelbower RR, et al.Image fusion of SPECT and CT[J]. J Nucl Med, 1997,38:319~323.
[5] Bolch WE, Bouchet LG, Roberson JS, et al. MRD pamphlet No. 17[J]. J Nucl Med, 1999, 40:11S~36S
[6] Loevinger R. Internally administered radioisotopes[A].Hine GJ, Brownell GL, eds. Radiation Dosimetry[M].New York:Academic Press, 1956. 693~799.
[7] Erdi AK, Yoke ED, Loew M H, et al. Use of the fast hartley transform for three-dimensional dose calculation in radionuclide therapy[J]. Med Phys, 1998, 11:2226~2233.
[8] Keal PJ, Hoban PW. Superposition dose calculation incorporating Monte Carlo generated electron track kernels[J]. Med Phys, 1996, 23:247~255.
[9] Furhang EE, Chui CS, Sgouros G.A Monte Carlo approach to patient-specific dosimetry[J]. Med Phys,1996, 23:1523~1529.

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备注/Memo

备注/Memo:
收稿日期:1999-12-28。
作者简介:徐志勇(1970-),男,浙江奉化人,常州肿瘤医院工程师,现在中国医学科学院中国协和医科大学放射医学研究所,硕士研究生,主要从事物理剂量的研究。
更新日期/Last Update: 1900-01-01