[1]杨敏.123I-epidepride:多巴胺D2受体显像剂[J].国际放射医学核医学杂志,2000,24(2):67-70.
　YANG Min.123I-epidepride: an imaging agent for dopamine D2 receptor[J].International Journal of Radiation Medicine and Nuclear Medicine,2000,24(2):67-70.
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
24
期数:
2000年第2期
页码:
67-70
栏目:
综述
出版日期:
1900-01-01

文章信息/Info

Title:
123I-epidepride: an imaging agent for dopamine D2 receptor
作者:
杨敏
214063 江苏 无锡, 江苏省原子医学研究所
Author(s):
YANG Min
Jiangsu Institute of Nuclear Medicine, Jiangsu Wuxi 214063, China
关键词:
123I-epidepride; 多巴胺D2受体; 单光子发射计算机断层显像
Keywords:
123I-epidepride; dopamine D2 receptor; single photon emission computed tomography
分类号:
R817.4
摘要:
123I-epidepride是一种较好的多巴胺D2受体SPCET显像剂,其亲和力高(Kd=24pmol/L),亲脂性相对较低(lgKw=2.05),适于纹状体和纹状体外造影,在垂体腺瘤显像中有较高的临床应用价值,并可预测一些垂体腺瘤对多巴胺治疗的反应。
Abstract:
123I-epidepride, 123I-(s)-N-[(1-ethyl-2-pyrrolidinyl) methyl]-5-iodo-2, 3-dimethoxybenzamide,is a potent imaging agent for SPECT of dopamine D2 receptor. With high affinity (Kd=24pmol/L) and relatively low lipophilicity (lgKw=2.05), it’s suitable for imaging in striated and extrastriated. In addition, it has high value in imaging of dopamine D2 receptors in pituitary adenoma, and it can serve as a predictor for response to dopamine agonist treatment.

参考文献/References:

[1] Kuikka JT, Hiltunen J, Foged C, et al. Initial human study with single-photone emission tomography using iodine-123-labelled 3-(5-cyclopropyl-1-2-4-oxadiazo-3-yl)-7-iodo-5-6-dihydro-5-methyl-6-oxo-4H-imidazo[1, 5-a] [1, 4]-benzodiazopine[J]. Eur J Nucl Med, 1996, 23:798~803.
[2] Leslie WD, Abrams DN, Greenberg CR, et al. Comparison of iodine-123-epidepride and iodine-123-IBZM for dopamine D2 receptor imaging[J]. J Nucl Med, 1998, 37:1589~1591.
[3] Kuikka JT, Akerman KK, Hiltunen J, et al. Striatal and extrastriatal imaging of dopamine D2 receptors in the living human brain with [125I] epidepride single-photon emission tomography[J]. Eur J Nucl Med, 1997, 24:483~487.
[4] Langer O,Halldin C,Dolle F,et al.Carbon-11 epidepride:a suitable radioligand for PET investigation of striatal and extrastrial dopamine D2 receptors[J]. Nucl Med Biol, 1999, 28:509~518.
[5] Pirker W, Asenbaum S, Wenger S, et al. Iodine-123-epidepride-SPECT:studies in Parkinson’s disease, multiple system atrophy and Huntington’s disease[J]. J Nucl Med, 1997, 38:1711~1717.
[6] Pricker W, Riedl M,Luger A, et al. Dopamine D2 receptor imaging in pituitary adenomas using iodine-123-epidepride and SPECT[J]. J Nucl Med, 1996, 37:1931~1937.
[7] De Herder WW, Reijs AEM,de Swart J, et al. Comparison of iodine-123-epidepride and iodine-123 IBZM for dopamine D2 receptor imaging in clinically non-functioning pituitary macroadenomas and macroprolactinomas[J]. Eur J Nucl Med, 1999, 26:46~50.

备注/Memo

备注/Memo:
收稿日期:2000-01-10。
作者简介:杨敏(1972-),女,江苏靖江人,江苏省原子医学研究所助理研究员,硕士,主要从事多巴胺D2受体显像剂123I-epidepride的研究。
更新日期/Last Update: 1900-01-01