[1]朱毓华,鲁佳荧,张慧玮,等.FBP和OSEM对正常人脑内多巴胺转运体分布半定量值影响的研究[J].国际放射医学核医学杂志,2018,(5):409-413.[doi:10.3760/cma.j.issn.1673-4114.2018.05.004]
 Zhu Yuhua,Lu Jiaying,Zhang Huiwei,et al.Effects of the different PET image reconstruction methods on distribution of dopamine transporter in healthy human brain[J].International Journal of Radiation Medicine and Nuclear Medicine,2018,(5):409-413.[doi:10.3760/cma.j.issn.1673-4114.2018.05.004]
点击复制

FBP和OSEM对正常人脑内多巴胺转运体分布半定量值影响的研究(/HTML)
分享到:

《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
期数:
2018年第5期
页码:
409-413
栏目:
临床研究
出版日期:
2018-10-01

文章信息/Info

Title:
Effects of the different PET image reconstruction methods on distribution of dopamine transporter in healthy human brain
作者:
朱毓华1 鲁佳荧1 张慧玮1 葛璟洁1 吴平1 鲍伟奇1 琚紫昭2 王坚3 管一晖14 左传涛14
1. 200235 上海, 复旦大学附属华山医院PET中心;
2. 200235 上海, 复旦大学附属华山医院核医学科;
3. 200235 上海, 复旦大学附属华山医院神经内科;
4. 200040 上海, 复旦大学医学功能与分子影像研究所
Author(s):
Zhu Yuhua1 Lu Jiaying1 Zhang Huiwei1 Ge Jingjie1 Wu Ping1 Bao Weiqi1 Ju Zizhao2 Wang Jian3 Guan Yihui14 Zuo Chuantao14
1. PET Center, Huashan Hospital, Fudan University, Shanghai 200235, China;
2. Department of Nuclear Medicine, Huashan Hospital, Fudan University, Shanghai 200235, China;
3. Department of Neurology, Huashan Hospital, Fudan University, Shanghai 200235, China;
4. Institute of Functional and Molecular Medical Imaging, Fudan University, Shanghai 200040, China
关键词:
多巴胺质膜转运蛋白质类正电子发射断层显像术滤波反投影迭代
Keywords:
Dopamine plasma membrane transport proteins Positron-emission tomography Filtered backprojectionIterative
DOI:
10.3760/cma.j.issn.1673-4114.2018.05.004
摘要:
目的 研究不同PET重建方法对正常人脑内多巴胺转运体(DAT)分布半定量值的影响。方法 将2014年3月至2015年6月期间41例健康受试者(正常人)的11C-甲基-N-2β-甲基酯-3β-(4-氟-苯基)托烷(11C-CFT )PET图像分别进行滤波反投影法(FBP)和有序子集最大期望值迭代法(OSEM)重建,自动勾画尾状核、壳核前部和后部等感兴趣脑区,以缺乏DAT分布的顶枕皮质作为参考区,按公式计算DAT分布的半定量值。DAT分布半定量值的组间比较采用配对t检验,相关性分析采用Pearson相关分析法。结果 基于OSEM重建的PET图像中DAT分布半定量值分别为:尾状核(1.77~2.15)、壳核前部(2.17~2.39)、壳核后部(1.71~2.06);基于FBP重建的PET图像中DAT分布半定量值分别为:尾状核(1.68~2.10)、壳核前部(2.07~2.37)、壳核后部(1.62~1.96)。基于OSEM重建的PET图像中双侧尾状核、壳核前部及后部的DAT分布半定量值均显著高于基于FBP重建的PET图像,且两者间的差异均有统计学意义(t=9.658~15.859,均P=0.000)。Pearson相关性分析结果显示,基于OSEM与FBP重建的PET图像的DAT分布半定量值在双侧尾状核、壳核前部及后部均呈显著正相关(R2=0.907~0.951,均P=0.000)。基于OSEM与FBP重建的PET图像中双侧尾状核、壳核前部及后部DAT分布半定量值均呈现随年龄增长逐渐减低的趋势。结论 不同PET重建方法获得的正常人脑内DAT分布半定量值存在显著差异,在多中心或纵向研究中需要保持PET图像重建方法的一致性。
Abstract:
Objective To study the effect of the reconstruction method on the semi-quantitative distribution of dopamine transporter (DAT) in the brain, 2β-carbomethoxy-3β- (4-fluorophe-nyl)- (N-11C-methyl)tropane (11C-CFT) PET images of healthy subjects were reconstructed by different PET reconstruction methods. Methods From March 2014 to June 2015, the 11C-CFT PET images of 41 healthy subjects were reconstructed by filtering back projection (FBP) method and ordered subsets expectation maximization (OSEM) iterative method. The brain regions of interest (ROI), namely, caudate nucleus, anterior putamen, and posterior shell nucleus, were automatically sketched with the parietal and occipital cortex lacking of DAT distribution as reference regions. The semi-quantitative value of DAT distribution was calculated using the following formula:radioactivity count of ROI/radioactivity count of parietal and occipital cortex-1. Paired t-test was used to compare the semi-quantitative values of DAT distribution. Correlation analysis was performed using the Pearson correlation analysis. Results The values of DAT distribution based on OSEM were as follows:caudate nucleus (1.77-2.15), anterior putamen (2.17-2.39), and posterior putamen (1.71-2.06). The values of DAT distribution based on FBP were as follows:caudate nucleus (1.68-2.10), anterior putamen (2.07-2.37), and posterior putamen (1.62-1.96). In the bilateral caudate nucleus and anterior and posterior putamen, the 11C-CFT of DAT distribution by OSEM was significantly higher than that by FBP (t=9.658-15.859, all P=0.000). The Pearson correlation analysis showed that the semi-quantitative values of DAT distribution by FBP and OSEM were positively correlated with each other in the bilateral caudate nucleus and anterior and posterior putamen (R2=0.907-0.951, all P=0.000). The DAT distribution by OSEM and FBP decreased with aging in the caudate nucleus and anterior and posterior putamen. Conclusions A significant difference was found in the semi-quantitative value of the DAT distribution in the brain of healthy subjects by different PET reconstruction methods. Therefore, a consistent PET image reconstruction method should be used in a multicenter or longitudinal study.

参考文献/References:

[1] Moreau C, Meguig S, Corvol JC, et al. Polymorphism of the dopamine transporter type 1 gene modifies the treatment response in Parkinson’s disease[J]. Brain, 2015, 138 (Pt 5):1271-1283. DOI:10.1093/brain/awv063.
[2] Lin JJ, Yueh KC, Chang DC, et al. The homozygote 10-copy genotype of variable number tandem repeat dopamine transporter gene may confer protection against Parkinson’s disease for male, but not to female patients[J]. J Neurol Sci, 2003, 209 (1/2):87-92.
[3] 刘丰韬, 王坚. 遗传性帕金森病患者的脑功能显像[J]. 内科理论与实践, 2010, 5 (5):438-441. DOI:10.16138/j.1673-6087. 2010. 05.007. Liu FT, Wang J. Functional neuroimging in patients with inherited Parkinsonism[J]. J Intern Med Concepts Pract, 2010, 5 (5):438-441.
[4] Ma Y, Dhawan V, Mentis M, et al. Parametric mapping of[18F]FPCIT binding in early stage Parkinson’s disease:a PET study[J]. Synapse, 2002, 45 (2):125-133. DOI:10.1002/syn.10090.
[5] Liu SY, Wu JJ, Zhao J, et al. Onset-related subtypes of Parkinson’s disease differ in the patterns of striatal dopaminergic dysfunction:A positron emission tomography study[J]. Parkinsonism Relat Disord, 2015, 21 (12):1448-1453. DOI:10.1016/j.parkreldis.2015.10.017.
[6] Postuma RB, Berg D, Stern M, et al. MDS clinical diagnostic criteria for Parkinson’s disease[J]. Mov Disord, 2015, 30 (12):1591-1601. DOI:10.1002/mds.26424.
[7] Guo JF, Wang L, He D, et al. Clinical features and[11C]-CFT PET analysis of PARK2, PARK6, PARK7-linked autosomal recessive early onset Parkinsonism[J]. Neurol Sci, 2011, 32 (1):35-40. DOI:10.1007/s10072-010-0360-z.
[8] Peng F, Sun YM, Chen C, et al. The heterozygous R1441C mutation of leucine-rich repeat kinase 2 gene in a Chinese patient with Parkinson disease:A five-year follow-up and literatures review[J]. J Neurol Sci, 2017, 373:23-26. DOI:10.1016/j.jns.2016.12.009.
[9] Shi CH, Mao CY, Zhang SY, et al. CHCHD2 gene mutations in familial and sporadic Parkinson’s disease[J/OL]. Neurobiol Aging, 2016, 38:217.e9-217.e13[2018-01-15]. http://www.ncbi.nlm.nih.gov/pubmed/26705026. DOI:10.1016/j.neurobiolaging.2015.10.040.
[10] 王元元, 吴平, 左传涛, 等. 不同重建算法对帕金森病相关脑功能网络的影响[J]. 中国医学计算机成像杂志, 2013, 19 (6):549-552. DOI:10.19627/j.cnki.cn31-1700/th.2013.06.018. Wang YY, Wu P, Zuo CT, et al. Influence of Different PET Reconstruction Algorithms on Parkinson’s Disease-related Pattern Expression[J]. Chin Comput Med Imag, 2013, 19 (6):549-552.
[11] 邱春, 左传涛, 张政伟, 等. 不同显像时间窗对11C-CFT PET/CT显像测多巴胺转运蛋白分布半定量值的影响[J]. 中华核医学与分子影像杂志, 2013, 33 (5):362-366. DOI:10.3760/cma.j.issn.2095-2848.2013.05.012. Qiu C, Zuo CT, Zhang ZW, et al. Influence of scanning time window on the binding potentials of dopamine transporter in the brain of healthy volunteers with 11C-CFT PET imaging[J]. Chin J Nucl Med Mol Imaging, 2013, 33 (5):362-366.
[12] Ramos CD, Erdi YE, Gonen M, et al. FDG-PET standardized uptake values in normal anatomical structures using iterative reconstruction segmented attenuation correction and filtered back-projection[J]. Eur J Nucl Med, 2001, 28 (2):155-164.

相似文献/References:

[1]何燕,苏晋,郑晓霞,等.P-糖蛋白抑制剂在PET显像中的应用研究[J].国际放射医学核医学杂志,2016,40(1):1.[doi:10.3760/cma.j.issn.1673-4114.2016.01.001]
 He Yan,Su Jin,ZhengXiaoxia,et al.Developing P-glycoprotein inhibitor marked by PET[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(5):1.[doi:10.3760/cma.j.issn.1673-4114.2016.01.001]
[2]许飞,刘建军,黄钢,等.PET乏氧显像在预测肿瘤乏氧及指导临床治疗中的应用进展[J].国际放射医学核医学杂志,2016,40(1):35.[doi:10.3760/cma.j.issn.1673-4114.2016.01.008]
 Xu Fei,Liu Jianjun,Huang Gang,et al.The application of hypoxia imaging with PET in predicting tumor hypoxia and guiding clinical therapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(5):35.[doi:10.3760/cma.j.issn.1673-4114.2016.01.008]
[3]胡伟,赵军.小胶质细胞在AD炎性机制中的作用及其常见PET显像剂的应用进展[J].国际放射医学核医学杂志,2016,40(1):44.[doi:10.3760/cma.j.issn.1673-4114.2016.01.009]
 Hu Wei,Zhao Jun.Microglia’s Alzheimer disease inflammatory mechanisms and progress of its common application in PET imaging agents[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(5):44.[doi:10.3760/cma.j.issn.1673-4114.2016.01.009]
[4]张莹莹,王振光,孔艳.PET/CT显像在肺间质纤维化中的应用进展[J].国际放射医学核医学杂志,2016,40(1):55.[doi:10.3760/cma.j.issn.1673-4114.2016.01.011]
 Zhang Yingying,Wang Zhenguang,Kong Yan.Application advancement on PET/CT in pulmonary interstitial fibrosis[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(5):55.[doi:10.3760/cma.j.issn.1673-4114.2016.01.011]
[5]李海峰,张晓军,李云钢,等.国产模块LOOP环改良法合成11C-蛋氨酸[J].国际放射医学核医学杂志,2016,40(2):106.[doi:10.3760/cma.j.issn.1673-4114.2016.02.004]
 Li Haifeng,Zhang Xiaojun,Li Yungang,et al.Synthesis of 11C-methionine on home-made module by the improved LOOP method[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(5):106.[doi:10.3760/cma.j.issn.1673-4114.2016.02.004]
[6]史文杰,孟召伟,谭建.基于Deauville标准探讨18F-FDG PET/CT在霍奇金淋巴瘤复发诊断中的应用价值[J].国际放射医学核医学杂志,2016,40(2):120.[doi:10.3760/cma.j.issn.1673-4114.2016.02.007]
 Shi Wenjie,Meng Zhaowei,Tan Jian.Value of 18F-FDG PET/CT on diagnosis of Hodgkin lymphoma recurrence using Deauville criterion[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(5):120.[doi:10.3760/cma.j.issn.1673-4114.2016.02.007]
[7]李海峰,张晓军,张锦明.多巴胺转运蛋白显像剂11C-β-CFT在帕金森病中的应用研究[J].国际放射医学核医学杂志,2016,40(3):218.[doi:10.3760/cma.j.issn.1673-4114.2016.03.011]
 Li Haifeng,Zhang Xiaojun,Zhang Jinming.Review of the use of dopamine transporter imaging agent 11C-β-CFT for diagnosing Parkinson disease[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(5):218.[doi:10.3760/cma.j.issn.1673-4114.2016.03.011]
[8]尤阳,轩昂,张杰,等.淋巴瘤患者大脑静息葡萄糖代谢改变[J].国际放射医学核医学杂志,2016,40(4):255.[doi:10.3760/cma.j.issn.1673-4114.2016.04.003]
 You Yang,Xuan Ang,Zhang Jie,et al.Changes in resting-state brain glucose metabolism in patients with lymphoma[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(5):255.[doi:10.3760/cma.j.issn.1673-4114.2016.04.003]
[9]王朋,崔邦平,代文莉,等.18F-FDG PET/CT在前列腺癌中的应用进展[J].国际放射医学核医学杂志,2016,40(4):277.[doi:10.3760/cma.j.issn.1673-4114.2016.04.008]
 Wang Peng,Cui Bangping,Dai Wenli,et al.Progress in the application of 18F-FDG PET/CT in prostate cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(5):277.[doi:10.3760/cma.j.issn.1673-4114.2016.04.008]
[10]李菲,黄俊星,张俊.18F-FDG PET/CT在食管癌中的临床应用[J].国际放射医学核医学杂志,2016,40(4):282.[doi:10.3760/cma.j.issn.1673-4114.2016.04.009]
 Li Fei,Huang Junxing,Zhang Jun.The clinical application of 18F-FDG PET/CT in esophageal cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(5):282.[doi:10.3760/cma.j.issn.1673-4114.2016.04.009]
[11]柴黎明,杨小丰,王爽,等.多巴胺转运体显像剂11C-CFT和18F-CFT及其临床应用进展[J].国际放射医学核医学杂志,2009,33(4):232.[doi:10.3760/cma.j.issn.1673-4114.2009.04.012]
 CHAI Li-ming,YANG Xiao-feng,WANG Shuang,et al.Dopamine transporter imaging agent 11C-CFT and 18F-CFT and its clinical application development[J].International Journal of Radiation Medicine and Nuclear Medicine,2009,33(5):232.[doi:10.3760/cma.j.issn.1673-4114.2009.04.012]
[12]于江,段玉清,毕常芬,等.多巴胺转运体PET显像剂11C-Altropane的研究进展[J].国际放射医学核医学杂志,2018,(1):74.[doi:10.3760/cma.j.issn.1673-4114.2018.01.014]
 Yu Jiang,Duan Yuqing,Bi Changfen,et al.Progress of dopamine transporter PET imaging agent 11C-Altropane[J].International Journal of Radiation Medicine and Nuclear Medicine,2018,(5):74.[doi:10.3760/cma.j.issn.1673-4114.2018.01.014]

备注/Memo

备注/Memo:
收稿日期:2018-01-15。
基金项目:国家自然科学基金(81671239、81571345、81771372、81701250);国家重点研发计划(2016YFC1306403、2016YFC1306500);上海市青年科技英才扬帆计划(16YF1415400)
通讯作者:张慧玮,Email:zhanghuiwei@huashan.org.cn
更新日期/Last Update: 2018-10-01