[1]姚晓龙,孙灿文,娜仁花,等.18F-FDG PET/CT对非小细胞肺癌纵隔淋巴结转移诊断价值的Meta分析[J].国际放射医学核医学杂志,2018,(1):53-57.[doi:10.3760/cma.j.issn.1673-4114.2018.01.010]
 Yao Xiaolong,Sun Canwen,Na Renhua,et al.Diagnostic value of 18F-FDG PET/CT in the diagnosis of mediastinal lymph node metastasis in non-small cell lung cancer: a Meta-analysis[J].International Journal of Radiation Medicine and Nuclear Medicine,2018,(1):53-57.[doi:10.3760/cma.j.issn.1673-4114.2018.01.010]
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18F-FDG PET/CT对非小细胞肺癌纵隔淋巴结转移诊断价值的Meta分析(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
期数:
2018年第1期
页码:
53-57
栏目:
Meta分析
出版日期:
2018-03-20

文章信息/Info

Title:
Diagnostic value of 18F-FDG PET/CT in the diagnosis of mediastinal lymph node metastasis in non-small cell lung cancer: a Meta-analysis
作者:
姚晓龙 孙灿文 娜仁花 何霖 古丽菲拉·海克甫 杨小丰
830001 乌鲁木齐, 新疆维吾尔自治区人民医院核医学科
Author(s):
Yao Xiaolong Sun Canwen Na Renhua He Lin Gulifeila Haikefu Yang Xiaofeng
Department of Nuclear Medicine, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, China
关键词:
非小细胞肺淋巴结转移正电子发射断层显像术体层摄影术X线计算机氟脱氧葡萄糖F18Meta分析
Keywords:
Carcinomanon-small-cell lungLymph node metastasisPositron-emission tomographyTomographyX-ray computedFluorodeoxyglucose F18Meta-analysis
DOI:
10.3760/cma.j.issn.1673-4114.2018.01.010
摘要:
目的 用Meta分析的方法评估18F-FDG PET/CT对于非小细胞肺癌(NSCLC)纵隔淋巴结转移的诊断价值。方法 通过检索万方数据库、中国知网、维普数据库、PubMed、Embase、Cochrane Library数据库,根据相应的检索词,收集1990年至2016年的所有PET/CT对NSCLC纵隔淋巴结诊断的发表文献,通过严格的纳入排除标准进行筛选,提取纳入文献中PET/CT对NSCLC纵隔淋巴结诊断的灵敏度、特异度、阳性似然比(PLR)、阴性似然比(NLR)、诊断比值比(DOR)并进行分析。阈值效应分析采用计算曲线下面积;亚组分析采用t检验。结果 共纳入文献22篇,患者2543例。以患者为研究对象,总灵敏度为0.66(0.62~0.69),总特异度为0.82(0.80~0.84),总PLR为3.60(2.82~4.58),总NLR为0.45(0.37~0.54),总DOR为9.12(6.15~13.52),曲线下面积为0.826。亚组分析结果显示,患有肺结核病史的与无肺结核病史的特异度差异有统计学意义(t=2.98,P<0.05),提示肺结核病史是影响PET/CT诊断NSCLC纵隔淋巴结转移的一个重要因素。结论 18F-FDG PET/CT是诊断NSCLC纵隔淋巴结转移的良好方法,可为NSCLC提供准确分期。
Abstract:
Objective To assess the diagnostic value of 18F-FDG PET/CT on mediastinal lymph node(MLN) metastasis in non-small cell lung cancer(NSCLC) by Meta analysis. Methods Publications on MLN staging of NSCLC by PET/CT published from 1990 to 2016 were filtered and assessed according to the criteria from Wanfang, China National Knowledge Infrastructure, Vip database, PubMed, Embase, Cochrane Library database. Receiver operating characteristic curve analysis was applied and senstivity, specificity, positive likelihood ratio(PLR), negative likelihood ratio(NLR), diagnostic odds ratio(DOR) were calculated. The threshold effect analysis uses the area under the calculated curve. Subgroup analysis adopted t test. Results Twenty-two relevant literatures were enrolled (including 2543 patients). Meta analysis showed that the pooled senstivity, specificity, PLR, NLR and DOR were 0.66(0.62-0.69), 0.82(0.80-0.84), 3.60(2.82-4.58), 0.45(0.37-0.54), 9.12(6.15-13.52), respectively. Area under curve was 0.826. The results of subgroup analysis suggested that there was a statistically significant difference between the history of tuberculosis and no history of tuberculosis, and pulmonary tuberculosis was one important factor which influenced the PET/CT diagnosis of MLN metastasis in NSCLC patients. Conclusion PET/CT has a high accuracy for the MLN staging in NSCLC patients.

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备注/Memo

备注/Memo:
收稿日期:2017-07-22。
通讯作者:杨小丰,Email:yangxf5100@126.com
更新日期/Last Update: 2018-03-20