[1]朱娅华,邓玮玮,范敏,等.18F-FDG PET/CT显像在胃癌分期及治疗方案制定中的应用价值[J].国际放射医学核医学杂志,2018,(1):15-20.[doi:10.3760/cma.j.issn.1673-4114.2018.01.003]
　Zhu Yahua,Deng Weiwei,Fan Min,et al.Value of 18F-FDG PET/CT imaging on the staging of gastric carcinoma and its influence on therapeutic schedule formulation[J].International Journal of Radiation Medicine and Nuclear Medicine,2018,(1):15-20.[doi:10.3760/cma.j.issn.1673-4114.2018.01.003]
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18F-FDG PET/CT显像在胃癌分期及治疗方案制定中的应用价值(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
期数:
2018年第1期
页码:
15-20
栏目:
临床研究
出版日期:
2018-03-20

文章信息/Info

Title:
Value of 18F-FDG PET/CT imaging on the staging of gastric carcinoma and its influence on therapeutic schedule formulation
作者:
朱娅华;  邓玮玮;  范敏;  郑文璐;  张春银
646000 泸州, 西南医科大学附属医院核医学科
Author(s):
Zhu Yahua;  Deng Weiwei;  Fan Min;  Zheng Wenlu;  Zhang Chunyin
Department of Nuclear Medicine, the Affiliated Hospital of Southwest Medical University, Luzhou 646000, China
关键词:
胃肿瘤; 氟脱氧葡萄糖F18; 正电子发射断层显像术; 体层摄影术; X线计算机
Keywords:
Stomach neoplasms; Fluorodeoxyglucose F18; Positron-emission tomography; Tomography; X-ray computed
DOI:
10.3760/cma.j.issn.1673-4114.2018.01.003
摘要:
目的 探讨18F-FDG PET/CT显像在胃癌分期及治疗方案制定中的应用价值。方法 回顾性分析46例临床疑诊胃癌患者的18F-FDG PET/CT图像，采用目测法和半定量法对患者PET/CT图像进行分析，即测定SUVmax与最大胃壁厚度（Tmax），以胃镜或手术后取得的病理结果作为“金标准”，评估18F-FDG PET/CT显像对病灶的诊断效能，并采用Pearson相关分析法分析SUVmax与Tmax的相关性。结果 18F-FDG PET/CT诊断原发病灶的灵敏度、特异度和准确率分别为94.4%、40.0%和82.6%；原发灶SUVmax与Tmax呈正相关（r=0.922，P=0.001）；18F-FDG PET/CT诊断淋巴结转移及远处转移的灵敏度、特异度和准确率分别为76.9%、90.0%、82.6%和92.9%、96.9%、95.7%。结论 18F-FDG PET/CT在检测胃癌的原发病灶、淋巴结转移灶和远处转移灶时有较高的特异度和灵敏度，在评估临床分期、指导临床制定正确的治疗方案中具有重要的应用价值。
Abstract:
Objective To explore the value of the 18F-FDG PET/CT imaging on the staging of gastric carcinoma and its influence on therapeutic schedule formulation. Methods A retrospective analysis on the 18F-FDG PET/CT images of 46 patients with suspected clinical diagnosis of gastric cancer was performed through visual and semiquantitative evaluation by detecting the SUVmax and the maximum gastric wall thickness (Tmax). Subsequently, the diagnostic efficiency of the 18F-FDG PET/CT imaging for lesions was assessed by comparing with the pathology obtained from gastroscopy or postoperative pathology. Pearson correlation analysis was used to analyze the correlation between SUVmax and Tmax. Results The sensitivity, specificity, and accuracy of 18F-FDG PET/CT imaging in detecting primary lesions were 94.4%, 40.0%, and 82.6%, respectively. The SUVmax of the primary lesions was positively correlated with the Tmax (r=0.922, P=0.001). The sensitivity, specificity, and accuracy of 18F-FDG PET/CT imaging were 76.9%, 90.0%, and 82.6% in detecting lymph node metastasis and 92.9%, 96.9%, and 95.7%, respectively, in recognizing distant metastasis. Conclusions 18F-FDG PET/CT imaging showed high specificity and sensitivity in detecting primary foci, lymph node metastasis, and distant metastasis of gastric cancer. This technique is also remarkably important in accurate assessment of the clinical stage and therapeutic schedule formulation.

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备注/Memo

备注/Memo:
收稿日期:2017-07-12。
通讯作者:张春银,Email:zhangchunyin345@sina.com
更新日期/Last Update: 2018-03-20