[1]高骏,段玉清,于江,等.新型PET显像剂18F-FACBC在前列腺癌中的应用进展[J].国际放射医学核医学杂志,2017,41(4):288-293.[doi:10.3760/cma.j.issn.1673-4114.2017.04.010]
 Gao Jun,Duan Yuqing,Yu Jiang,et al.Application of new PET imaging agent 18F-FACBC in prostate cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2017,41(4):288-293.[doi:10.3760/cma.j.issn.1673-4114.2017.04.010]
点击复制

新型PET显像剂18F-FACBC在前列腺癌中的应用进展(/HTML)
分享到:

《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
41
期数:
2017年第4期
页码:
288-293
栏目:
综述
出版日期:
2017-07-25

文章信息/Info

Title:
Application of new PET imaging agent 18F-FACBC in prostate cancer
作者:
高骏 段玉清 于江 李祎亮
300192, 天津, 中国医学科学院北京协和医学院放射医学研究所, 天津市放射医学与核医学重点实验室
Author(s):
Gao Jun Duan Yuqing Yu Jiang Li Yiliang
Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Science and Peking Union Medical College, Tianjin 300192, China
关键词:
前列腺肿瘤正电子发射断层显像术复发18F-FACBC
Keywords:
Prostatic neoplasmsPositron-emission tomographyRelapse18F-FACBC
DOI:
10.3760/cma.j.issn.1673-4114.2017.04.010
摘要:
前列腺癌(PCa)患者在接受治疗后,约33%患者在10至15年内复发。这时利用PET/CT对病灶的精确定位和发展阶段的分析就显得十分重要。目前用于诊断PCa的PET显像剂主要有18F-FDG、11C-胆碱、18F-胆碱、68Ga-前列腺特异性膜抗原(68Ga-PSMA)等。但是由于PCa细胞对18F-FDG摄取差、11C-胆碱半衰期短等原因,使得PCa诊断效果不理想。18F-氟环丁烷羧酸(18F-FACBC)显像剂具有对PCa细胞特异性强、半衰期长、制备简单等优点,具备成为诊断PCa新型PET显像剂的潜力。
Abstract:
Patients who successfully complete treatment for prostate cancer face an almost 33% chance of disease recurrence in the next 10 to 15 years,during which the positioning of the lesion and its development stage should be precisely identified using PET/CT.PET imaging agents that are currently used to diagnose PCa are 18F-FDG,11C-choline,18F-choline,and 68Ga-prostate-specific membrane antigen (68Ga-PSMA).However,the diagnosis of PCa is insufficient due to the poor intake of 18F-FDG in PCa cells and the short half-life of 11C-choline.18F-fluorocyclobutane carboxylic acid (18F-FACBC) has the advantages of strong specificity of PCa cells,long half-life,and simple preparation requirements and can therefore be an imaging agent for PCa diagnosis.

参考文献/References:

[1] Siegel RL, Miller KD, Jemal A. Cancer statistics, 2017[J]. CA Cancer J Clin, 2017, 67(1):7-30. DOI:10.3322/caac.21387.
[2] Simsir A, Cal C, Mammadov R, et al. Biochemical recurrence after radical prostatectomy:is the disease or the surgeon to blame?[J]. Inter Braz J Urol, 2011, 37(3):328-335. DOI:10.1590/S1677-55382011000300006.
[3] Avril N, Dambha F, Murray I, et al. The clinical advances of fluo-rine-2-D-deoxyglucose-positron emission tomography/computed tomography in urological cancers[J]. Int J Urol, 2010, 17(6):501-511. DOI:10.1111/j.1442-2042.2010.02509.x.
[4] Lindenberg L, Choyke P, Dahut W. Prostate cancer imaging with novel PET tracers[J]. Curr Urol Rep, 2016, 17(3):18. DOI:10.1007/s11934-016-0575-5.
[5] Bauman G, Belhocine T, Kovacs M, et al. 18F-fluorocholine for prostate cancer imaging:a systematic review of the literature[J]. Prostate Cancer Prostatic Dis, 2012, 15(1):45-55. DOI:10.1038/pcan.2011.35.
[6] Krause BJ, Souvatzoglou M, Treiber U. Imaging of prostate cancer with PET/CT and radioactively labeled choline derivates[J]. Urol Oncol, 2013, 31(4):427-435.
[7] Roethke MC, Kuru TH, Afshar-Oromieh A, et al. Hybrid positron emission tomography-magnetic resonance imaging with Gallium 68 prostate-specific membrane antigen tracer:a next step for imaging of recurrent prostate cancer-preliminary results[J]. Eur Urol,2013, 64(5):862-864. DOI:10.1016/j.eururo.2013.08.003.
[8] Afshar-Oromieh A, Zechmann CM, Malcher A, et al. Comparison of PET imaging with a (68)Ga-labelled PSMA ligand and (18)F-choline-based PET/CT for the diagnosis of recurrent prostate cancer[J]. Eur J Nucl Med Mol Imaging, 2014, 41(1):11-20. DOI:10.1007/s00259-013-2525-5.
[9] Afshar-Oromieh A, Avtzi E, Giesel FL, et al. The diagnostic value of PET/CT imaging with the (68)Ga-labelled PSMA ligand HBED-CC in the diagnosis of recurrent prostate cancer[J]. Eur J Nucl Med Mol Imaging, 2015, 42(2):197-209. DOI:10.1007/s00259-014-2949-6.
[10] Eiber M, Maurer T, Souvatzoglou M, et al. Evaluation of hybrid 68Ga-PSMA ligand PET/CT in 248 patients with biochemical recurrence after radical prostatectomy[J]. J Nucl Med, 2015, 56(5):668-674. DOI:10.2967/jnumed.115.154153.
[11] Eiber M, Weirich G, Holzapfel K, et al. 68Ga-PSMA HBED-CC PET/MRI in intermediate and high-risk prostate cancer improves the intraprostatic tumor localization compared to multiparametric Mr[J/OL]. J Nucl Med, 2016, 57(Suppl 2):28[2017-03-01]. http://jnm.snmjournals.org/content/57/supplement_2/28.short.
[12] Maurer T, Gschwend JE, Rauscher I, et al. Diagnostic efficacy of (68)Gallium-PSMA positron emission tomography compared to conventional imaging for lymph node staging of 130 consecutive patients with intermediate to high risk prostate cancer[J]. J Urol, 2016, 195(5):1436-1443. DOI:10.1016/j.juro.2015.12.025.
[13] Washburn LC, Sun TT, Byrd B, et al. 1-aminocyclobutane[11C]car-boxylic acid, a potential tumor-seeking agent[J]. J Nucl Med,1979, 20(10):1055-1061.
[14] Shoup TM, Goodman MM. Synthesis of[F-18]-1-amino-3-fluorocy-clobutane-1-carboxylic acid (FACBC):A PET tracer for tumor delineation[J]. J Labelled Comp Radiopharm, 1999, 42(3):215-225.DOI:10.1002/(SICI)1099-1344(199903)42:3<215:AID-JLCR180>3.0.CO;2-0.
[15] Okudaira H, Shikano N, Nishii R, et al. Putative transport mechanism and intracellular fate of trans-1-amino-3-18F-fluorocyclobu-tanecarboxylic acid in human prostate cancer[J]. J Nucl Med, 2011, 52(5):822-829. DOI:10.2967/jnumed.110.086074.
[16] Oka S, Hattori R, Kurosaki F, et al. A preliminary study of anti-1-amino-3-18F-fluorocyclobutyl-1-carboxylic acid for the detection of prostate cancer[J]. J Nucl Med, 2007, 48(1):46-55.
[17] Kairemo K, Rasulova N, Partanen K, et al. Preliminary clinical experience of trans-1-amino-3-(18)F-fluorocyclobutanecarboxylic acid (anti-(18) F-FACBC) PET/CT imaging in prostate cancer patients[J/OL]. Biomed Res Int, 2014:305182[2017-03-02]. https://www.hindawi.com/journals/bmri/2014/305182/. DOI:10.1155/2014/305182.
[18] Schuster DM, Taleghani PA, Nieh PT, et al. Characterization of primary prostate carcinoma by anti-1-amino-2-[(18)F]-fluorocyclobu-tane-1-carboxylic acid (anti-3-[(18)F] FACBC) uptake[J]. Am J Nucl Med Mol Imaging, 2013, 3(1):85-96.
[19] S?rensen J, Owenius R, Lax M, et al. Regional distribution and kinetics of[18F]fluciclovine (anti-[18F]FACBC), a tracer of amino acid transport, in subjects with primary prostate cancer[J]. Eur J Nucl Med Mol Imaging, 2013, 40(3):394-402. DOI:10.1007/s00259-012-2291-9.
[20] Turkbey B, Mena E, Shih J, et al. Localized prostate cancer detection with 18F FACBC PET/CT:comparison with Mr imaging and histopa-thologic analysis[J]. Radiology, 2014, 270(3):849-856. DOI:10.1148/radiol.13130240.
[21] Nanni C, Schiavina R, Boschi S, et al. Comparison of 18F-FACBC and 11C-choline PET/CT in patients with radically treated prostate cancer and biochemical relapse:preliminary results[J]. Eur J Nucl Med Mol Imaging, 2013, 40 Suppl 1:S11-17. DOI:10.1007/s00259-013-2373-3.
[22] McConathy J, Voll RJ, Yu W, et al. Improved synthesis of anti-[18F]FACBC:improved preparation of labeling precursor and automated radiosynthesis[J]. Appl Radiat Isot, 2003, 58(6):657-666.
[23] Chaly T, Dahl JR. Thin layer chromatographic detection of kryptofix 2.2.2 in the routine synthesis of[18F]2-fluoro-2-deoxy-D-glucose[J].Int J Rad Appl Instrum B, 1989, 16(4):385-387. DOI:10.1016/0883-2897(89)90105-0.
[24] Schuster DM, Votaw JR, Nieh PT, et al. Initial experience with the radiotracer anti-1-amino-3-18F-fluorocyclobutane-1-carboxylic acid with PET/CT in prostate carcinoma[J]. J Nucl Med, 2007, 48(1):56-63. DOI:10.1007/s00259-008-0993-9.
[25] Schuster DM, Savir-Baruch B, Nieh PT, et al. Detection of recurrent prostate carcinoma with anti-1-amino-3-18F-fluorocyclobutane-1-carboxylic acid PET/CT and 111In-capromab pendetide SPECT/CT[J]. Radiology, 2011, 259(3):852-861. DOI:10.1148/radiol.11102023.
[26] Shuster JR, Lance RS, Troyer DA. Molecular preservation by extraction and fixation, mPREF:a method for small molecule biomarker analysis and histology on exactly the same tissue[J]. BMC Clin Pathol, 2011, 11(1):14. DOI:10.1186/1472-6890-11-14.
[27] Chillarón J, Estévez R, Mora C, et al. Obligatory amino acid exchange via systems bo,+-like and y+L-like. A tertiary active transport mechanism for renal reabsorption of cystine and dibasic amino acids[J]. J Biol Chem,1996, 271(30):17761-17770. DOI:10.1074/jbc.271.30.17761.
[28] Romeo E, Dave MH, Bacic D, et al. Luminal kidney and intestine SLC6 amino acid transporters of B0AT-cluster and their tissue distribution in Mus musculus[J]. Am J Physiol Renal Physiol, 2006, 290(2):F376-383. DOI:10.1152/ajprenal.00286.2005.
[29] Bodoy S, Martín L, Zorzano A, et al. Identification of LAT4, a novel amino acid transporter with system L activity[J]. J Biol Chem, 2005, 280(12):12002-12011. DOI:10.1074/jbc.M408638200.
[30] Park SY, Kim JK, Kim IJ, et al. Reabsorption of neutral amino acids mediated by amino acid transporter LAT2 and TAT1 in the basolateral membrane of proximal tubule[J]. Arch Pharm Res, 2005, 28(4):421-432. DOI:10.1007/BF02977671.
[31] Kanagawa M, Doi Y, Oka S, et al. Comparison of trans-1-amino-3-[18F]fluorocyclobutanecarboxylic acid (anti-[18F]FACBC) accumulation in lymph node prostate cancer metastasis and lymphadenitis in rats[J]. Nucl Med Biol, 2014, 41(7):545-551. DOI:10.1016/j.nucmedbio.2014.04.004.
[32] Asano Y, Inoue Y, Ikeda Y, et al.Phase I clinical study of NMK36:a new PET tracer with the synthetic amino acid analogue anti-[18F]FACBC[J]. Ann Nucl Med, 2011, 25(6):414-418. DOI:10.1007/s12149-011-0477-z.
[33] Inoue Y, Asano Y, Satoh T, et al. Phase Ⅱa clinical trial of trans-1-amino-3-(18)F-fluoro-cyclobutane carboxylic acid in metastatic prostate cancer[J]. Asia Ocean J Nucl Medi Biol, 2014, 2(2):87-94.
[34] Nanni C, Schiavina R, Rubello D, et al. The detection of disease relapse after radical treatment for prostate cancer:is anti-3-18F-FACBC PET/CT a promising option?[J]. Nucl Med Commun, 2013, 34(9):831-833. DOI:10.1097/MNM.0b013e3283636eaf.
[35] Tolvanen T, Yli-Kerttula T, Ujula T, et al. Biodistribution and radiation dosimetry of[11C]choline:a comparison between rat and human data[J]. Eur J Nucl Med Mol Imaging, 2010, 37(5):874-883. DOI:10.1007/s00259-009-1346-z.
[36] Inoue Y, Asano Y, Satoh T, et al. Phase Ⅱa clinical trial of trans-1-amino-3-18F-fluoro-cyclobutane carboxylic acid in metastatic prostate cancer[J]. Asia Ocean J Nucl Medi Biol, 2014, 2(2):87-94.
[37] Ren J, Yuan L, Wen G, et al. The value of anti-1-amino-3-18F-fluo-rocyclobutane-1-carboxylic acid PET/CT in the diagnosis of recur-rent prostate carcinoma:a meta-analysis[J]. Acta radiologica, 2015, 57(4):487-493. DOI:10.1177/0284185115581541.

相似文献/References:

[1]何燕,苏晋,郑晓霞,等.P-糖蛋白抑制剂在PET显像中的应用研究[J].国际放射医学核医学杂志,2016,40(1):1.[doi:10.3760/cma.j.issn.1673-4114.2016.01.001]
 He Yan,Su Jin,ZhengXiaoxia,et al.Developing P-glycoprotein inhibitor marked by PET[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(4):1.[doi:10.3760/cma.j.issn.1673-4114.2016.01.001]
[2]许飞,刘建军,黄钢,等.PET乏氧显像在预测肿瘤乏氧及指导临床治疗中的应用进展[J].国际放射医学核医学杂志,2016,40(1):35.[doi:10.3760/cma.j.issn.1673-4114.2016.01.008]
 Xu Fei,Liu Jianjun,Huang Gang,et al.The application of hypoxia imaging with PET in predicting tumor hypoxia and guiding clinical therapy[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(4):35.[doi:10.3760/cma.j.issn.1673-4114.2016.01.008]
[3]胡伟,赵军.小胶质细胞在AD炎性机制中的作用及其常见PET显像剂的应用进展[J].国际放射医学核医学杂志,2016,40(1):44.[doi:10.3760/cma.j.issn.1673-4114.2016.01.009]
 Hu Wei,Zhao Jun.Microglia’s Alzheimer disease inflammatory mechanisms and progress of its common application in PET imaging agents[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(4):44.[doi:10.3760/cma.j.issn.1673-4114.2016.01.009]
[4]张莹莹,王振光,孔艳.PET/CT显像在肺间质纤维化中的应用进展[J].国际放射医学核医学杂志,2016,40(1):55.[doi:10.3760/cma.j.issn.1673-4114.2016.01.011]
 Zhang Yingying,Wang Zhenguang,Kong Yan.Application advancement on PET/CT in pulmonary interstitial fibrosis[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(4):55.[doi:10.3760/cma.j.issn.1673-4114.2016.01.011]
[5]李海峰,张晓军,李云钢,等.国产模块LOOP环改良法合成11C-蛋氨酸[J].国际放射医学核医学杂志,2016,40(2):106.[doi:10.3760/cma.j.issn.1673-4114.2016.02.004]
 Li Haifeng,Zhang Xiaojun,Li Yungang,et al.Synthesis of 11C-methionine on home-made module by the improved LOOP method[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(4):106.[doi:10.3760/cma.j.issn.1673-4114.2016.02.004]
[6]史文杰,孟召伟,谭建.基于Deauville标准探讨18F-FDG PET/CT在霍奇金淋巴瘤复发诊断中的应用价值[J].国际放射医学核医学杂志,2016,40(2):120.[doi:10.3760/cma.j.issn.1673-4114.2016.02.007]
 Shi Wenjie,Meng Zhaowei,Tan Jian.Value of 18F-FDG PET/CT on diagnosis of Hodgkin lymphoma recurrence using Deauville criterion[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(4):120.[doi:10.3760/cma.j.issn.1673-4114.2016.02.007]
[7]李海峰,张晓军,张锦明.多巴胺转运蛋白显像剂11C-β-CFT在帕金森病中的应用研究[J].国际放射医学核医学杂志,2016,40(3):218.[doi:10.3760/cma.j.issn.1673-4114.2016.03.011]
 Li Haifeng,Zhang Xiaojun,Zhang Jinming.Review of the use of dopamine transporter imaging agent 11C-β-CFT for diagnosing Parkinson disease[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(4):218.[doi:10.3760/cma.j.issn.1673-4114.2016.03.011]
[8]尤阳,轩昂,张杰,等.淋巴瘤患者大脑静息葡萄糖代谢改变[J].国际放射医学核医学杂志,2016,40(4):255.[doi:10.3760/cma.j.issn.1673-4114.2016.04.003]
 You Yang,Xuan Ang,Zhang Jie,et al.Changes in resting-state brain glucose metabolism in patients with lymphoma[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(4):255.[doi:10.3760/cma.j.issn.1673-4114.2016.04.003]
[9]李菲,黄俊星,张俊.18F-FDG PET/CT在食管癌中的临床应用[J].国际放射医学核医学杂志,2016,40(4):282.[doi:10.3760/cma.j.issn.1673-4114.2016.04.009]
 Li Fei,Huang Junxing,Zhang Jun.The clinical application of 18F-FDG PET/CT in esophageal cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(4):282.[doi:10.3760/cma.j.issn.1673-4114.2016.04.009]
[10]张巍,杨珂.18f正电子放射性药物生产及使用中医务人员的受照剂量研究[J].国际放射医学核医学杂志,2015,39(5):420.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 016]
 zhang wei,yang ke..the research of radiation dose of 18f-fdg to pet/ct related personnel[J].International Journal of Radiation Medicine and Nuclear Medicine,2015,39(4):420.[doi:10. 3760 / cma. j. issn. 1673-4114. 2015. 05. 016]
[11]王朋,崔邦平,代文莉,等.18F-FDG PET/CT在前列腺癌中的应用进展[J].国际放射医学核医学杂志,2016,40(4):277.[doi:10.3760/cma.j.issn.1673-4114.2016.04.008]
 Wang Peng,Cui Bangping,Dai Wenli,et al.Progress in the application of 18F-FDG PET/CT in prostate cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(4):277.[doi:10.3760/cma.j.issn.1673-4114.2016.04.008]
[12]廖光星,冷志欣,肖国有.前列腺癌骨转移影像诊断方法研究进展[J].国际放射医学核医学杂志,2016,40(6):464.[doi:10.3760/cma.j.issn.1673-4114.2016.06.012]
 Liao Guangxing,Leng Zhixin,Xiao Guoyou.Progress of imaging in the diagnosis of bone metastases of prostate cancer[J].International Journal of Radiation Medicine and Nuclear Medicine,2016,40(4):464.[doi:10.3760/cma.j.issn.1673-4114.2016.06.012]
[13]徐慧琴,薛杨央,赵学峰,等.18F-FDG PET-CT诊断前列腺癌复发与转移的价值[J].国际放射医学核医学杂志,2011,35(2):81.[doi:10.3760/cma.j.issn.1673-4114.2011.02.004]
 XU Hui-qin,XUE Yang-yang,ZHAO Xue-feng,et al.Value of 18F-FDG PET-CT in diagnoss of prostate cancer recurrence and metastasis[J].International Journal of Radiation Medicine and Nuclear Medicine,2011,35(4):81.[doi:10.3760/cma.j.issn.1673-4114.2011.02.004]

备注/Memo

备注/Memo:
收稿日期:2017-03-02。
基金项目:中国医学科学院医学与健康科技新工程资助(2016-12M-3-022)
通讯作者:李祎亮,Email:liyiliang75@163.com
更新日期/Last Update: 2017-07-31