[1]程林,程竞仪.氨基酸类正电子显像在胶质瘤中的研究进展[J].国际放射医学核医学杂志,2017,41(4):283-287.[doi:10.3760/cma.j.issn.1673-4114.2017.04.009]
 Cheng Lin,Cheng Jingyi.Research progress on glioma imaging using amino acid PET[J].International Journal of Radiation Medicine and Nuclear Medicine,2017,41(4):283-287.[doi:10.3760/cma.j.issn.1673-4114.2017.04.009]
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氨基酸类正电子显像在胶质瘤中的研究进展(/HTML)
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《国际放射医学核医学杂志》[ISSN:1673-4114/CN:12-1381/R]

卷:
41
期数:
2017年第4期
页码:
283-287
栏目:
综述
出版日期:
2017-07-25

文章信息/Info

Title:
Research progress on glioma imaging using amino acid PET
作者:
程林12 程竞仪12
1. 201321, 上海市质子重离子医院核医学科;
2. 200032, 上海, 复旦大学附属肿瘤医院核医学科
Author(s):
Cheng Lin12 Cheng Jingyi12
1. Department of Nuclear Medicine, Shanghai Proton and Heavy Ion Center, Shanghai 201321, China;
2. Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, Shanghai 200032, China
关键词:
神经胶质瘤甲硫氨酸酪氨酸正电子发射断层显像术
Keywords:
GliomaMethionineTyrosinePositron-emission tomography
DOI:
10.3760/cma.j.issn.1673-4114.2017.04.009
摘要:
胶质瘤是神经系统中较常见的疾病之一,严重危害人类健康,其预后取决于分期、手术切除情况、组织学分类、病理分级等。氨基酸类正电子显像剂如11C-蛋氨酸(11C-MET)、18F-酪氨酸(18F-FET)等在胶质瘤PET显像中有较为广泛的应用。11C-MET和18F-FET作为氨基酸类显像剂既可以反映人体内的氨基酸转运、代谢和蛋白质合成,又可以对胶质瘤进行早期诊断、分级、鉴别坏死与复发、放疗靶区的勾画及判断预后等,对其临床诊疗有较大的价值。笔者就两种氨基酸类显像剂在胶质瘤中的应用现状进行综述。
Abstract:
Glioma is one of the common diseases of the nervous system,and it poses hazards to human health.Prognosis of glioma depends on staging,surgical resection,histological classification,and pathological grading.Both 11C-L-methionine and 18F-fluoroethyl tyrosine are popular amino acid tracers used in PET imaging of brain tumors and reflect amino acid transport,metabolism,and protein synthesis in vivo.A literature overview on the role of amino acid PET in glioma is provided in terms of diagnostic accuracy,grading,differentiation of tumor recurrence and radiation necrosis,radiotherapy planning,and prognosis.

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备注/Memo

备注/Memo:
收稿日期:2017-01-12。
通讯作者:程竞仪,Email:jingyi.cheng@sphic.org.cn
更新日期/Last Update: 2017-07-31